Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis

Vetterli, Laurene Marine; Maechler, Pierre

doi:10.18632/aging.100304

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Title		Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis
Authors		Vetterli, Laurene Marine Maechler, Pierre
Published in		Aging. 2011, vol. 3, no. 4, p. 444-9
Abstract		Sirtuins are energy sensors which mediate effects of calorie restriction-induced lifespan extension. The mammalian sirtuin homolog SIRT1 is a protein deacetylase playing a central role in metabolic homeostasis. SIRT1 is one of the targets of resveratrol, a polyphenol that has been shown to increase lifespan and to protect animal models against high-calorie diet induced obesity and insulin resistance. The beneficial effects of resveratrol mediated by SIRT1 activation can be contributed by different organs. Among them, the liver and pancreatic β-cells have been shown to be responsive to resveratrol in a SIRT1-dependent manner. Downstream of SIRT1, transcription factors being activated are tissue-specific, in turn inducing expression of metabolic genes in an apparent paradoxical way. In this review, we discuss specificities of SIRT1 effects in the liver versus pancreatic β-cells, ultimately converging towards metabolic homeostasis at the organism level.
Keywords		Adenylate Kinase/metabolism — Animals — Antioxidants/pharmacology — Energy Metabolism/drug effects — Enzyme Activation/drug effects — Glucose/metabolism — Homeostasis/drug effects — Insulin/metabolism — Insulin-Secreting Cells/drug effects/metabolism — Liver/cytology/drug effects/metabolism — Sirtuin 1/metabolism — Stilbenes/pharmacology — Transcription Factors/metabolism
Identifiers		DOI: 10.18632/aging.100304 PMID: 21483037
Full text		Article (Published version) (776 Kb) - Limited access to UNIGE Other version: http://www.impactaging.com/papers/v3/n4/full/100304.html
Structures		Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Research group		Mitochondries et sécrétion d'insuline (671)
Citation (ISO format)		VETTERLI, Laurene Marine, MAECHLER, Pierre. Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis. In: Aging, 2011, vol. 3, n° 4, p. 444-9. doi: 10.18632/aging.100304 https://archive-ouverte.unige.ch/unige:25506