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Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis

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Published in Aging. 2011, vol. 3, no. 4, p. 444-9
Abstract Sirtuins are energy sensors which mediate effects of calorie restriction-induced lifespan extension. The mammalian sirtuin homolog SIRT1 is a protein deacetylase playing a central role in metabolic homeostasis. SIRT1 is one of the targets of resveratrol, a polyphenol that has been shown to increase lifespan and to protect animal models against high-calorie diet induced obesity and insulin resistance. The beneficial effects of resveratrol mediated by SIRT1 activation can be contributed by different organs. Among them, the liver and pancreatic β-cells have been shown to be responsive to resveratrol in a SIRT1-dependent manner. Downstream of SIRT1, transcription factors being activated are tissue-specific, in turn inducing expression of metabolic genes in an apparent paradoxical way. In this review, we discuss specificities of SIRT1 effects in the liver versus pancreatic β-cells, ultimately converging towards metabolic homeostasis at the organism level.
Keywords Adenylate Kinase/metabolismAnimalsAntioxidants/pharmacologyEnergy Metabolism/drug effectsEnzyme Activation/drug effectsGlucose/metabolismHomeostasis/drug effectsInsulin/metabolismInsulin-Secreting Cells/drug effects/metabolismLiver/cytology/drug effects/metabolismSirtuin 1/metabolismStilbenes/pharmacologyTranscription Factors/metabolism
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PMID: 21483037
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Research group Mitochondries et sécrétion d'insuline (671)
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VETTERLI, Laurene Marine, MAECHLER, Pierre. Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis. In: Aging, 2011, vol. 3, n° 4, p. 444-9. https://archive-ouverte.unige.ch/unige:25506

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Deposited on : 2013-01-14

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