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Title

Whole-genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain

Authors
Nair, Dhanalakshmi
Memmi, Guido
Bard, Jonathan
Beaume, Marie
Gill, Steven
Cheung, Ambrose L
Published in Journal of Bacteriology. 2011, vol. 193, no. 9, p. 2332-5
Abstract Staphylococcus aureus RN4220, a cloning intermediate, is sometimes used in virulence, resistance, and metabolic studies. Using whole-genome sequencing, we showed that RN4220 differs from NCTC8325 and contains a number of genetic polymorphisms that affect both virulence and general fitness, implying a need for caution in using this strain for such studies.
Keywords Chromosome MappingChromosomes, BacterialGene Expression Regulation, Bacterial/physiologyGenetic FitnessGenome, BacterialMutationStaphylococcus aureus/classification/genetics/pathogenicityStress, PhysiologicalVirulenceVirulence Factors/genetics/metabolism
Identifiers
PMID: 21378186
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Research group Analyse génomique et fonctionnelle du staphylocoque doré (604)
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NAIR, Dhanalakshmi et al. Whole-genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain. In: Journal of Bacteriology, 2011, vol. 193, n° 9, p. 2332-5. https://archive-ouverte.unige.ch/unige:25385

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Deposited on : 2013-01-11

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