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Title

Whole-genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain
Authors
Nair, Dhanalakshmi
Memmi, Guido
Hernandez, David
Bard, Jonathan
Beaume, Marie
Gill, Steven
Francois, Patrice
Cheung, Ambrose L
Published in Journal of Bacteriology. 2011, vol. 193, no. 9, p. 2332-5
Abstract Staphylococcus aureus RN4220, a cloning intermediate, is sometimes used in virulence, resistance, and metabolic studies. Using whole-genome sequencing, we showed that RN4220 differs from NCTC8325 and contains a number of genetic polymorphisms that affect both virulence and general fitness, implying a need for caution in using this strain for such studies.
Keywords Chromosome Mapping — Chromosomes, Bacterial — Gene Expression Regulation, Bacterial/physiology — Genetic Fitness — Genome, Bacterial — Mutation — Staphylococcus aureus/classification/genetics/pathogenicity — Stress, Physiological — Virulence — Virulence Factors/genetics/metabolism
Identifiers
PMID: 21378186
Full text
Article (Published version) (1.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Research group Analyse génomique et fonctionnelle du staphylocoque doré (604)
Citation
(ISO format) 		NAIR, Dhanalakshmi et al. Whole-genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain. In: Journal of Bacteriology, 2011, vol. 193, n° 9, p. 2332-5. doi: 10.1128/JB.00027-11 https://archive-ouverte.unige.ch/unige:25385

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Deposited on : 2013-01-11

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