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Whole-genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain |
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Published in | Journal of bacteriology. 2011, vol. 193, no. 9, p. 2332-5 | |
Abstract | Staphylococcus aureus RN4220, a cloning intermediate, is sometimes used in virulence, resistance, and metabolic studies. Using whole-genome sequencing, we showed that RN4220 differs from NCTC8325 and contains a number of genetic polymorphisms that affect both virulence and general fitness, implying a need for caution in using this strain for such studies. | |
Keywords | Chromosome Mapping — Chromosomes, Bacterial — Gene Expression Regulation, Bacterial/physiology — Genetic Fitness — Genome, Bacterial — Mutation — Staphylococcus aureus/classification/genetics/pathogenicity — Stress, Physiological — Virulence — Virulence Factors/genetics/metabolism | |
Identifiers | DOI: 10.1128/JB.00027-11 PMID: 21378186 | |
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Research group | Analyse génomique et fonctionnelle du staphylocoque doré (604) | |
Citation (ISO format) | NAIR, Dhanalakshmi et al. Whole-genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain. In: Journal of bacteriology, 2011, vol. 193, n° 9, p. 2332-5. doi: 10.1128/JB.00027-11 https://archive-ouverte.unige.ch/unige:25385 |