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Title

Focal adhesion remodeling is crucial for glucose-stimulated insulin secretion and involves activation of focal adhesion kinase and paxillin

Authors
Tomas, Alejandra
Published in Diabetes. 2011, vol. 60, no. 4, p. 1146-57
Abstract Actin cytoskeleton remodeling is known to be involved in glucose-stimulated insulin secretion (GSIS). We have observed glucose-stimulated changes at the β-cell basal membrane similar to focal adhesion remodeling in cell migration. This led us to study the role of two key focal adhesion proteins, focal adhesion kinase (FAK) and paxillin, in GSIS.
Keywords AnimalsBlotting, WesternCells, CulturedElectrophoresis, Polyacrylamide GelFlavonoids/pharmacologyFluorescent Antibody TechniqueFocal Adhesion Protein-Tyrosine Kinases/metabolismFocal Adhesions/drug effects/metabolismGlucose/pharmacologyInsulin/metabolismMicroscopy, ConfocalMitogen-Activated Protein Kinase 1/antagonists & inhibitors/metabolismMitogen-Activated Protein Kinase 3/antagonists & inhibitors/metabolismPaxillin/metabolismPhosphorylation/drug effectsRNA InterferenceRats
Identifiers
PMID: 21357465
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Article (Author postprint) (1.8 MB) - public document Free access
Structures
Research group Fonction de l'îlot de Langerhans (324)
Project FNS: 31003A_127276
Citation
(ISO format)
RONDAS, Dieter, TOMAS, Alejandra, HALBAN, Philippe A. Focal adhesion remodeling is crucial for glucose-stimulated insulin secretion and involves activation of focal adhesion kinase and paxillin. In: Diabetes, 2011, vol. 60, n° 4, p. 1146-57. https://archive-ouverte.unige.ch/unige:25378

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Deposited on : 2013-01-11

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