en
Scientific article
English

IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C

Published inJournal of hepatology, vol. 55, no. 5, p. 980-988
Publication date2011
Abstract

Single nucleotide polymorphisms (SNPs) associated with IL28B influence the outcome of peginterferon-α/ribavirin therapy of chronic hepatitis C virus (HCV) infection. We analyzed the kinetics of HCV RNA during therapy as a function of IL28B SNPs.

Keywords
  • Adult
  • Alleles
  • Antiviral Agents/therapeutic use
  • Female
  • Gene Frequency
  • Genotype
  • Hepacivirus/genetics/physiology
  • Hepatitis C, Chronic/drug therapy/genetics
  • Humans
  • Interferon-alpha/therapeutic use
  • Interleukins/genetics
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Polyethylene Glycols/therapeutic use
  • Polymorphism, Single Nucleotide/genetics
  • RNA, Viral/blood
  • Recombinant Proteins/therapeutic use
  • Ribavirin/therapeutic use
  • Time Factors
Citation (ISO format)
BOCHUD, Pierre-Yves et al. IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C. In: Journal of hepatology, 2011, vol. 55, n° 5, p. 980–988. doi: 10.1016/j.jhep.2011.01.050
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Article (Published version)
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ISSN of the journal0168-8278
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