IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C.

Bochud, Pierre-Yves; Bibert, Stéphanie; Negro, Francesco; Haagmans, B; Soulier, Anthony André; Ferrari, C; Missale, G; Zeuzem, S; Pawlotsky, J-M; Schalm, S; Hellstrand, K; Neumann, A U; Lagging, M

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Title		IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C.
Authors		Bochud, Pierre-Yves Bibert, Stéphanie Negro, Francesco Haagmans, B Soulier, Anthony André Ferrari, C Missale, G Zeuzem, S Pawlotsky, J-M Schalm, S Hellstrand, K Neumann, A U Lagging, M show all authors [1 - 13]
Published in		Journal of Hepatology. 2011, vol. 55, no. 5, p. 980-8
Abstract		Single nucleotide polymorphisms (SNPs) associated with IL28B influence the outcome of peginterferon-α/ribavirin therapy of chronic hepatitis C virus (HCV) infection. We analyzed the kinetics of HCV RNA during therapy as a function of IL28B SNPs.
Keywords		Adult — Alleles — Antiviral Agents/therapeutic use — Female — Gene Frequency — Genotype — Hepacivirus/genetics/physiology — Hepatitis C, Chronic/drug therapy/genetics — Humans — Interferon-alpha/therapeutic use — Interleukins/genetics — Male — Middle Aged — Multivariate Analysis — Polyethylene Glycols/therapeutic use — Polymorphism, Single Nucleotide/genetics — RNA, Viral/blood — Recombinant Proteins/therapeutic use — Ribavirin/therapeutic use — Time Factors
Identifiers		DOI: 10.1016/j.jhep.2011.01.050 PMID: 21354446
Full text		Article (Published version) (906 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group		Etudes et traitement de l'hépatite C et B (554)
Citation (ISO format)		BOCHUD, Pierre-Yves et al. IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C. In: Journal of Hepatology, 2011, vol. 55, n° 5, p. 980-8. https://archive-ouverte.unige.ch/unige:25376