IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C

Bochud, Pierre-Yves; Bibert, Stéphanie; Negro, Francesco; Haagmans, B; Soulier, Anthony André; Ferrari, C; Missale, G; Zeuzem, S; Pawlotsky, J-M; Schalm, S; Hellstrand, K; Neumann, A U; Lagging, M

doi:10.1016/j.jhep.2011.01.050

Scientific article

English

IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C

ContributorsBochud, Pierre-Yves; Bibert, Stéphanie; Negro, Francesco; Haagmans, B; Soulier, Anthony André; Ferrari, C; Missale, G; Zeuzem, S; Pawlotsky, J-M; Schalm, S; Hellstrand, K; Neumann, A U; Lagging, M

Published inJournal of hepatology, vol. 55, no. 5, p. 980-988

Publication date2011

Abstract

Single nucleotide polymorphisms (SNPs) associated with IL28B influence the outcome of peginterferon-α/ribavirin therapy of chronic hepatitis C virus (HCV) infection. We analyzed the kinetics of HCV RNA during therapy as a function of IL28B SNPs.

Keywords

Adult
Alleles
Antiviral Agents/therapeutic use
Female
Gene Frequency
Genotype
Hepacivirus/genetics/physiology
Hepatitis C, Chronic/drug therapy/genetics
Humans
Interferon-alpha/therapeutic use
Interleukins/genetics
Male
Middle Aged
Multivariate Analysis
Polyethylene Glycols/therapeutic use
Polymorphism, Single Nucleotide/genetics
RNA, Viral/blood
Recombinant Proteins/therapeutic use
Ribavirin/therapeutic use
Time Factors

Affiliation entities

Research groups

Etudes et traitement de l'hépatite C et B (554)

Citation (ISO format)

BOCHUD, Pierre-Yves et al. IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C. In: Journal of hepatology, 2011, vol. 55, n° 5, p. 980–988. doi: 10.1016/j.jhep.2011.01.050

Article (Published version)

Identifiers

PID : unige:25376
DOI : 10.1016/j.jhep.2011.01.050
PMID : 21354446

Journal ISSN0168-8278

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IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C

Single nucleotide polymorphisms (SNPs) associated with IL28B influence the outcome of peginterferon-α/ribavirin therapy of chronic hepatitis C virus (HCV) infection. We analyzed the kinetics of HCV RNA during therapy as a function of IL28B SNPs.

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