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Title

Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto-Kakizaki (GK) rat

Authors
Giroix, M-H
Lacraz, G
Noll, C
Calderari, S
Ehses, J A
Coulaud, J
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Published in Diabetologia. 2011, vol. 54, no. 9, p. 2451-62
Abstract The adult non-obese Goto-Kakizaki (GK) rat model of type 2 diabetes, particularly females, carries in addition to hyperglycaemia a genetic predisposition towards dyslipidaemia, including hypercholesterolaemia. As cholesterol-induced atherosclerosis may be programmed in utero, we looked for signs of perinatal lipid alterations and islet microangiopathy. We hypothesise that such alterations contribute towards defective pancreas/islet vascularisation that might, in turn, lead to decreased beta cell mass. Accordingly, we also evaluated islet inflammation and endothelial activation in both prediabetic and diabetic animals.
Keywords Aging/metabolismAnimalsAnimals, NewbornBlood Glucose/metabolismDiabetes Mellitus, Type 2/physiopathologyDiabetic Angiopathies/physiopathologyDisease Models, AnimalDisease ProgressionFemaleHypercholesterolemia/physiopathologyInsulin/bloodInsulin-Secreting Cells/pathologyIslets of Langerhans/blood supplyMaleNeovascularization, Pathologic/physiopathologyPredictive Value of TestsPregnancyRatsRats, Inbred StrainsRats, Wistar
Identifiers
PMID: 21744291
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Article (Author postprint) (324 Kb) - public document Free access
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Research group Fonction de l'îlot de Langerhans (324)
Project FNS: 31003A_127276
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(ISO format)
GIROIX, M-H et al. Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto-Kakizaki (GK) rat. In: Diabetologia, 2011, vol. 54, n° 9, p. 2451-62. https://archive-ouverte.unige.ch/unige:25370

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Deposited on : 2013-01-10

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