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PCR for the diagnosis of sepsis: hope or hype?

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Published in Critical Care. 2011, vol. 15, no. 1, p. 111
Abstract Molecular biology has not yet fully reached its ambitious goals in clinical bacteriology. Notwithstanding the tremendous technical challenges, the detection of nucleic acids directly from the blood of septic patients has not been shown cost-effective or even clinically relevant. Yet the potential for rapid molecular detection of circulating DNA (DNAemia) coupled to an educated antimicrobial drug adaptation has been repetitively advocated as a predicted breakthrough. Why do we still remain in such uncertainty?
Keywords Health Care CostsHumansModels, TheoreticalPolymerase Chain Reaction/economicsSepsis/economics/mortality
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PMID: 21345277
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Article (Published version) (113 Kb) - public document Free access
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Research group Analyse génomique et fonctionnelle du staphylocoque doré (604)
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SCHRENZEL, Jacques. PCR for the diagnosis of sepsis: hope or hype?. In: Critical Care, 2011, vol. 15, n° 1, p. 111. https://archive-ouverte.unige.ch/unige:25351

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Deposited on : 2013-01-10

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