ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells
Contributeurs/tricesBoergesen, Michael; Poulsen, Lars la Cour; Schmidt, Søren Fisker; Frigerio, Francesca; Maechler, Pierre ; Mandrup, Susanne
Publié dansThe Journal of biological chemistry, vol. 286, no. 15, p. 13214-13225
Date de publication2011
Résumé
Mots-clés
- Animals
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics/metabolism
- Cell Line, Tumor
- Exons/physiology
- Fatty Acids/genetics/metabolism
- Gene Expression Regulation/drug effects/physiology
- Gene Knockdown Techniques
- Glucose/metabolism/pharmacology
- HEK293 Cells
- Humans
- Insulin-Secreting Cells/cytology/metabolism
- Mice
- Nuclear Proteins/genetics/metabolism
- Oxidation-Reduction
- PPAR alpha/biosynthesis/genetics
- Protein Structure, Tertiary
- Rats
- Rats, Wistar
- Repressor Proteins/genetics/metabolism
- Sweetening Agents/metabolism/pharmacology
- Transcription Factors/genetics/metabolism
- Transcription, Genetic/drug effects/physiology
Structure d'affiliation
Groupe de recherche
Citation (format ISO)
BOERGESEN, Michael et al. ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells. In: The Journal of biological chemistry, 2011, vol. 286, n° 15, p. 13214–13225. doi: 10.1074/jbc.M110.215467
Fichiers principaux (1)
Article (Published version)
Identifiants
- PID : unige:25320
- DOI : 10.1074/jbc.M110.215467
- PMID : 21282101
ISSN du journal0021-9258