UNIGE document Scientific Article
previous document  unige:25306  next document
add to browser collection
Title

Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals: the Swiss HIV Cohort Study

Authors
Fehr, Jan
Glass, Tracy R
Louvel, Séverine
Hamy, François
Hirsch, Hans H
von Wyl, Viktor
Böni, Jürg
show hidden authors show all authors [1 - 19]
Published in Journal of Translational Medicine. 2011, vol. 9, p. 14
Abstract Replicative phenotypic HIV resistance testing (rPRT) uses recombinant infectious virus to measure viral replication in the presence of antiretroviral drugs. Due to its high sensitivity of detection of viral minorities and its dissecting power for complex viral resistance patterns and mixed virus populations rPRT might help to improve HIV resistance diagnostics, particularly for patients with multiple drug failures. The aim was to investigate whether the addition of rPRT to genotypic resistance testing (GRT) compared to GRT alone is beneficial for obtaining a virological response in heavily pre-treated HIV-infected patients.
Keywords AdultAnti-HIV Agents/pharmacology/therapeutic useCohort StudiesDose-Response Relationship, DrugDrug Resistance, Viral/physiologyFemaleGenotypeHIV Infections/diagnosis/drug therapy/virologyHIV-1/physiologyHumansMaleMicrobial Sensitivity Tests/methodsMiddle AgedPhenotypePredictive Value of TestsPrognosisSwitzerlandVirus Replication/drug effects/physiology
Identifiers
PMID: 21255386
Full text
Article (Published version) (254 Kb) - public document Free access
Structures
Research groups Groupe Laurent Kaiser (virologie clinique) (668)
Unité HIV (46)
Citation
(ISO format)
FEHR, Jan et al. Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals: the Swiss HIV Cohort Study. In: Journal of Translational Medicine, 2011, vol. 9, p. 14. https://archive-ouverte.unige.ch/unige:25306

182 hits

95 downloads

Update

Deposited on : 2013-01-10

Export document
Format :
Citation style :