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Scientific article
Open access
English

Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals: the Swiss HIV Cohort Study

Published inJournal of translational medicine, vol. 9, 14
Publication date2011
Abstract

Replicative phenotypic HIV resistance testing (rPRT) uses recombinant infectious virus to measure viral replication in the presence of antiretroviral drugs. Due to its high sensitivity of detection of viral minorities and its dissecting power for complex viral resistance patterns and mixed virus populations rPRT might help to improve HIV resistance diagnostics, particularly for patients with multiple drug failures. The aim was to investigate whether the addition of rPRT to genotypic resistance testing (GRT) compared to GRT alone is beneficial for obtaining a virological response in heavily pre-treated HIV-infected patients.

Keywords
  • Adult
  • Anti-HIV Agents/pharmacology/therapeutic use
  • Cohort Studies
  • Dose-Response Relationship, Drug
  • Drug Resistance, Viral/physiology
  • Female
  • Genotype
  • HIV Infections/diagnosis/drug therapy/virology
  • HIV-1/physiology
  • Humans
  • Male
  • Microbial Sensitivity Tests/methods
  • Middle Aged
  • Phenotype
  • Predictive Value of Tests
  • Prognosis
  • Switzerland
  • Virus Replication/drug effects/physiology
Citation (ISO format)
FEHR, Jan et al. Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals: the Swiss HIV Cohort Study. In: Journal of translational medicine, 2011, vol. 9, p. 14. doi: 10.1186/1479-5876-9-14
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1479-5876
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Technical informations

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