Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis

Cai, Tao; Dufour, Jean-François Jacques; Muellhaupt, Beat; Gerlach, Tilman Joern; Heim, Markus; Moradpour, Darius; Cerny, Andreas; Malinverni, Raffaele; Kaddai, Vincent; Bochud, Murielle; Negro, Francesco; Bochud, Pierre-Yves

doi:10.1016/j.jhep.2010.12.020

Professional article

English

Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis

ContributorsCai, Tao; Dufour, Jean-François Jacques; Muellhaupt, Beat; Gerlach, Tilman Joern; Heim, Markus; Moradpour, Darius; Cerny, Andreas; Malinverni, Raffaele; Kaddai, Vincent; Bochud, Murielle; Negro, Francesco; Bochud, Pierre-Yves

Published inJournal of hepatology, vol. 55, no. 3, p. 529-535

Publication date2011

Abstract

Steatosis is a prominent feature of hepatitis C, especially in patients infected with genotype 3. The analysis of genetic polymorphisms influencing steatosis in chronic hepatitis C has been limited by the studies' small sample size, and important single nucleotide polymorphisms (SNPs), such as those in the patatin-like phospholipase family 3 protein (PNPLA3), were never evaluated.

Keywords

Adult
Carrier Proteins/genetics
Fatty Liver/complications/genetics/virology
Female
Genotype
Hepacivirus/genetics
Hepatitis C, Chronic/complications/virology
Humans
Interleukins/genetics
Lipase/genetics
Logistic Models
Male
Membrane Proteins/genetics
Middle Aged
PPAR gamma/genetics
Polymorphism, Single Nucleotide
Severity of Illness Index

Affiliation entities

Research groups

Etudes et traitement de l'hépatite C et B (554)

Citation (ISO format)

CAI, Tao et al. Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis. In: Journal of hepatology, 2011, vol. 55, n° 3, p. 529–535. doi: 10.1016/j.jhep.2010.12.020

Article (Published version)

Identifiers

PID : unige:25297
DOI : 10.1016/j.jhep.2010.12.020
PMID : 21236304

Journal ISSN0168-8278

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Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis

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