Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis

Cai, Tao; Dufour, Jean-François Jacques; Muellhaupt, Beat; Gerlach, Tilman Joern; Heim, Markus; Moradpour, Darius; Cerny, Andreas; Malinverni, Raffaele; Kaddai, Vincent; Bochud, Murielle; Negro, Francesco; Bochud, Pierre-Yves

doi:10.1016/j.jhep.2010.12.020

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Title		Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis
Authors		Cai, Tao Dufour, Jean-François Jacques Muellhaupt, Beat Gerlach, Tilman Joern Heim, Markus Moradpour, Darius Cerny, Andreas Malinverni, Raffaele Kaddai, Vincent Bochud, Murielle Negro, Francesco Bochud, Pierre-Yves show all authors [1 - 12]
Published in		Journal of Hepatology. 2011, vol. 55, no. 3, p. 529-35
Abstract		Steatosis is a prominent feature of hepatitis C, especially in patients infected with genotype 3. The analysis of genetic polymorphisms influencing steatosis in chronic hepatitis C has been limited by the studies' small sample size, and important single nucleotide polymorphisms (SNPs), such as those in the patatin-like phospholipase family 3 protein (PNPLA3), were never evaluated.
Keywords		Adult — Carrier Proteins/genetics — Fatty Liver/complications/genetics/virology — Female — Genotype — Hepacivirus/genetics — Hepatitis C, Chronic/complications/virology — Humans — Interleukins/genetics — Lipase/genetics — Logistic Models — Male — Membrane Proteins/genetics — Middle Aged — PPAR gamma/genetics — Polymorphism, Single Nucleotide — Severity of Illness Index
Identifiers		DOI: 10.1016/j.jhep.2010.12.020 PMID: 21236304
Full text		Article (Published version) (622 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group		Etudes et traitement de l'hépatite C et B (554)
Citation (ISO format)		CAI, Tao et al. Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis. In: Journal of hepatology, 2011, vol. 55, n° 3, p. 529-35. doi: 10.1016/j.jhep.2010.12.020 https://archive-ouverte.unige.ch/unige:25297