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Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis

Published inJournal of hepatology, vol. 55, no. 3, p. 529-535
Publication date2011
Abstract

Steatosis is a prominent feature of hepatitis C, especially in patients infected with genotype 3. The analysis of genetic polymorphisms influencing steatosis in chronic hepatitis C has been limited by the studies' small sample size, and important single nucleotide polymorphisms (SNPs), such as those in the patatin-like phospholipase family 3 protein (PNPLA3), were never evaluated.

Keywords
  • Adult
  • Carrier Proteins/genetics
  • Fatty Liver/complications/genetics/virology
  • Female
  • Genotype
  • Hepacivirus/genetics
  • Hepatitis C, Chronic/complications/virology
  • Humans
  • Interleukins/genetics
  • Lipase/genetics
  • Logistic Models
  • Male
  • Membrane Proteins/genetics
  • Middle Aged
  • PPAR gamma/genetics
  • Polymorphism, Single Nucleotide
  • Severity of Illness Index
Citation (ISO format)
CAI, Tao et al. Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis. In: Journal of hepatology, 2011, vol. 55, n° 3, p. 529–535. doi: 10.1016/j.jhep.2010.12.020
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Identifiers
ISSN of the journal0168-8278
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