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Title

Ambiguous nucleotide calls from population-based sequencing of HIV-1 are a marker for viral diversity and the age of infection

Authors
Kouyos, Roger D
von Wyl, Viktor
Yerly, Sabine
Böni, Jürg
Joos, Beda
Shah, Cyril
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Published in Clinical Infectious Diseases. 2011, vol. 52, no. 4, p. 532-9
Abstract The time passed since the infection of a human immunodeficiency virus (HIV)-infected individual (the age of infection) is an important but often only poorly known quantity. We assessed whether the fraction of ambiguous nucleotides obtained from bulk sequencing as done for genotypic resistance testing can serve as a proxy of this parameter.
Keywords AdultCohort StudiesFemaleHIV Infections/virologyHIV-1/classification/genetics/isolation & purificationHumansMaleMiddle AgedPolymorphism, GeneticSequence Analysis, DNASwitzerlandTime FactorsPol Gene Products, Human Immunodeficiency Virus/genetics
Identifiers
PMID: 21220770
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Article (Published version) (312 Kb) - public document Free access
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Research groups Groupe Laurent Kaiser (virologie clinique) (668)
Unité HIV (46)
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KOUYOS, Roger D et al. Ambiguous nucleotide calls from population-based sequencing of HIV-1 are a marker for viral diversity and the age of infection. In: Clinical Infectious Diseases, 2011, vol. 52, n° 4, p. 532-9. https://archive-ouverte.unige.ch/unige:25291

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Deposited on : 2013-01-10

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