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Scientific article
Open access
English

Ambiguous nucleotide calls from population-based sequencing of HIV-1 are a marker for viral diversity and the age of infection

Published inClinical infectious diseases, vol. 52, no. 4, p. 532-539
Publication date2011
Abstract

The time passed since the infection of a human immunodeficiency virus (HIV)-infected individual (the age of infection) is an important but often only poorly known quantity. We assessed whether the fraction of ambiguous nucleotides obtained from bulk sequencing as done for genotypic resistance testing can serve as a proxy of this parameter.

Keywords
  • Adult
  • Cohort Studies
  • Female
  • HIV Infections/virology
  • HIV-1/classification/genetics/isolation & purification
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Sequence Analysis, DNA
  • Switzerland
  • Time Factors
  • Pol Gene Products, Human Immunodeficiency Virus/genetics
Citation (ISO format)
KOUYOS, Roger D et al. Ambiguous nucleotide calls from population-based sequencing of HIV-1 are a marker for viral diversity and the age of infection. In: Clinical infectious diseases, 2011, vol. 52, n° 4, p. 532–539. doi: 10.1093/cid/ciq164
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1058-4838
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Technical informations

Creation10/25/2012 12:37:00 PM
First validation10/25/2012 12:37:00 PM
Update time03/14/2023 7:55:31 PM
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