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β-cell regeneration: the pancreatic intrinsic faculty

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Published in Trends in Endocrinology and Metabolism. 2011, vol. 22, no. 1, p. 34-43
Abstract Type I diabetes (T1D) patients rely on cumbersome chronic injections of insulin, making the development of alternate durable treatments a priority. The ability of the pancreas to generate new β-cells has been described in experimental diabetes models and, importantly, in infants with T1D. Here we discuss recent advances in identifying the origin of new β-cells after pancreatic injury, with and without inflammation, revealing a surprising degree of cell plasticity in the mature pancreas. In particular, the inducible selective near-total destruction of β-cells in healthy adult mice uncovers the intrinsic capacity of differentiated pancreatic cells to spontaneously reprogram to produce insulin. This opens new therapeutic possibilities because it implies that β-cells can differentiate endogenously, in depleted adults, from heterologous origins.
Keywords AnimalsCell Differentiation/genetics/physiologyDiabetes Mellitus/metabolism/pathologyHumansInsulin-Secreting Cells/cytology/metabolism/physiologyPancreas/cytologyRegeneration/physiology
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PMID: 21067943
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Article (Published version) (319 Kb) - public document Free access
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Research group Types cellulaires pancréatiques pendant l'ontogénèse (522)
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DESGRAZ, Renaud, BONAL, Claire Brune, HERRERA, Pedro Luis. β-cell regeneration: the pancreatic intrinsic faculty. In: Trends in Endocrinology and Metabolism, 2011, vol. 22, n° 1, p. 34-43. https://archive-ouverte.unige.ch/unige:25186

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Deposited on : 2013-01-09

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