en
Scientific article
Meta-analysis
Open access
English

β-cell regeneration: the pancreatic intrinsic faculty

Published inTrends in endocrinology and metabolism, vol. 22, no. 1, p. 34-43
Publication date2011
Abstract

Type I diabetes (T1D) patients rely on cumbersome chronic injections of insulin, making the development of alternate durable treatments a priority. The ability of the pancreas to generate new β-cells has been described in experimental diabetes models and, importantly, in infants with T1D. Here we discuss recent advances in identifying the origin of new β-cells after pancreatic injury, with and without inflammation, revealing a surprising degree of cell plasticity in the mature pancreas. In particular, the inducible selective near-total destruction of β-cells in healthy adult mice uncovers the intrinsic capacity of differentiated pancreatic cells to spontaneously reprogram to produce insulin. This opens new therapeutic possibilities because it implies that β-cells can differentiate endogenously, in depleted adults, from heterologous origins.

Keywords
  • Animals
  • Cell Differentiation/genetics/physiology
  • Diabetes Mellitus/metabolism/pathology
  • Humans
  • Insulin-Secreting Cells/cytology/metabolism/physiology
  • Pancreas/cytology
  • Regeneration/physiology
Citation (ISO format)
DESGRAZ, Renaud, BONAL, Claire Brune, HERRERA, Pedro Luis. β-cell regeneration: the pancreatic intrinsic faculty. In: Trends in endocrinology and metabolism, 2011, vol. 22, n° 1, p. 34–43. doi: 10.1016/j.tem.2010.09.004
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1043-2760
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