Scientific article

Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii

Published inAntimicrobial agents and chemotherapy, vol. 56, no. 2, p. 1087-1089
Publication date2012

A multidrug-resistant Acinetobacter baumannii isolate recovered from a patient hospitalized in Switzerland after a transfer from Serbia produced the NDM-1 carbapenemase. The bla(NDM-1) gene was part of a chromosomally located Tn125 composite transposon bracketed by two copies of the same insertion sequence, ISAba125. This transposon was also associated with the acquisition and expression of the bla(NDM-2) gene in an A. baumannii isolate in Germany. Tn125 appears to be the main vehicle for dissemination of bla(NDM) genes in that species.

  • Acinetobacter Infections/epidemiology/microbiology
  • Acinetobacter baumannii/drug effects/enzymology/genetics
  • Anti-Bacterial Agents/pharmacology
  • Bacterial Proteins/genetics
  • Carbapenems/pharmacology
  • DNA Transposable Elements/genetics
  • Drug Resistance, Multiple, Bacterial
  • Gene Transfer, Horizontal/genetics
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Sequence Analysis, DNA
  • Switzerland/epidemiology
  • Beta-Lactam Resistance
  • Beta-Lactamases/genetics
  • Beta-Lactams/pharmacology
Citation (ISO format)
POIREL, Laurent et al. Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii. In: Antimicrobial agents and chemotherapy, 2012, vol. 56, n° 2, p. 1087–1089. doi: 10.1128/AAC.05620-11
Main files (1)
Article (Published version)
ISSN of the journal0066-4804

Technical informations

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First validation10/18/2012 9:08:00 AM
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