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Scientific Article
unige:25164 
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Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii |
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| Published in | Antimicrobial Agents and Chemotherapy. 2012, vol. 56, no. 2, p. 1087-9 | |
| Abstract | A multidrug-resistant Acinetobacter baumannii isolate recovered from a patient hospitalized in Switzerland after a transfer from Serbia produced the NDM-1 carbapenemase. The bla(NDM-1) gene was part of a chromosomally located Tn125 composite transposon bracketed by two copies of the same insertion sequence, ISAba125. This transposon was also associated with the acquisition and expression of the bla(NDM-2) gene in an A. baumannii isolate in Germany. Tn125 appears to be the main vehicle for dissemination of bla(NDM) genes in that species. | |
| Keywords | Acinetobacter Infections/epidemiology/microbiology — Acinetobacter baumannii/drug effects/enzymology/genetics — Anti-Bacterial Agents/pharmacology — Bacterial Proteins/genetics — Carbapenems/pharmacology — DNA Transposable Elements/genetics — Drug Resistance, Multiple, Bacterial — Gene Transfer, Horizontal/genetics — Humans — Microbial Sensitivity Tests — Molecular Sequence Data — Sequence Analysis, DNA — Switzerland/epidemiology — Beta-Lactam Resistance — Beta-Lactamases/genetics — Beta-Lactams/pharmacology | |
| Identifiers | DOI: 10.1128/AAC.05620-11 PMID: 22143526 | |
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| Structures | ||
| Research group | Analyse génomique et fonctionnelle du staphylocoque doré (604) | |
| Citation (ISO format) | POIREL, Laurent et al. Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii. In: Antimicrobial Agents and Chemotherapy, 2012, vol. 56, n° 2, p. 1087-9. doi: 10.1128/AAC.05620-11 https://archive-ouverte.unige.ch/unige:25164 |
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