Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii

Poirel, Laurent; Bonnin, Rémy A; Boulanger, Anne; Schrenzel, Jacques; Kaase, Martin; Nordmann, Patrice

doi:10.1128/AAC.05620-11

Scientific article

English

Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii

ContributorsPoirel, Laurent; Bonnin, Rémy A; Boulanger, Anne; Schrenzel, Jacques; Kaase, Martin; Nordmann, Patrice

Published inAntimicrobial agents and chemotherapy, vol. 56, no. 2, p. 1087-1089

Publication date2012

Abstract

A multidrug-resistant Acinetobacter baumannii isolate recovered from a patient hospitalized in Switzerland after a transfer from Serbia produced the NDM-1 carbapenemase. The bla(NDM-1) gene was part of a chromosomally located Tn125 composite transposon bracketed by two copies of the same insertion sequence, ISAba125. This transposon was also associated with the acquisition and expression of the bla(NDM-2) gene in an A. baumannii isolate in Germany. Tn125 appears to be the main vehicle for dissemination of bla(NDM) genes in that species.

Keywords

Acinetobacter Infections/epidemiology/microbiology
Acinetobacter baumannii/drug effects/enzymology/genetics
Anti-Bacterial Agents/pharmacology
Bacterial Proteins/genetics
Carbapenems/pharmacology
DNA Transposable Elements/genetics
Drug Resistance, Multiple, Bacterial
Gene Transfer, Horizontal/genetics
Humans
Microbial Sensitivity Tests
Molecular Sequence Data
Sequence Analysis, DNA
Switzerland/epidemiology
Beta-Lactam Resistance
Beta-Lactamases/genetics
Beta-Lactams/pharmacology

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Analyse génomique et fonctionnelle du staphylocoque doré (604)

Citation (ISO format)

POIREL, Laurent et al. Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii. In: Antimicrobial agents and chemotherapy, 2012, vol. 56, n° 2, p. 1087–1089. doi: 10.1128/AAC.05620-11

Article (Published version)

Identifiers

PID : unige:25164
DOI : 10.1128/AAC.05620-11
PMID : 22143526

Journal ISSN0066-4804

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Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii

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