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Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii

Poirel, Laurent
Bonnin, Rémy A
Boulanger, Anne
Kaase, Martin
Nordmann, Patrice
Published in Antimicrobial agents and chemotherapy. 2012, vol. 56, no. 2, p. 1087-9
Abstract A multidrug-resistant Acinetobacter baumannii isolate recovered from a patient hospitalized in Switzerland after a transfer from Serbia produced the NDM-1 carbapenemase. The bla(NDM-1) gene was part of a chromosomally located Tn125 composite transposon bracketed by two copies of the same insertion sequence, ISAba125. This transposon was also associated with the acquisition and expression of the bla(NDM-2) gene in an A. baumannii isolate in Germany. Tn125 appears to be the main vehicle for dissemination of bla(NDM) genes in that species.
Keywords Acinetobacter Infections/epidemiology/microbiologyAcinetobacter baumannii/drug effects/enzymology/geneticsAnti-Bacterial Agents/pharmacologyBacterial Proteins/geneticsCarbapenems/pharmacologyDNA Transposable Elements/geneticsDrug Resistance, Multiple, BacterialGene Transfer, Horizontal/geneticsHumansMicrobial Sensitivity TestsMolecular Sequence DataSequence Analysis, DNASwitzerland/epidemiologyBeta-Lactam ResistanceBeta-Lactamases/geneticsBeta-Lactams/pharmacology
PMID: 22143526
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Research group Analyse génomique et fonctionnelle du staphylocoque doré (604)
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POIREL, Laurent et al. Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii. In: Antimicrobial agents and chemotherapy, 2012, vol. 56, n° 2, p. 1087-9. doi: 10.1128/AAC.05620-11 https://archive-ouverte.unige.ch/unige:25164

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Deposited on : 2013-01-09

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