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Multiple simultaneous synthesis of phenolic libraries

Meyers, Harold V.
Dilley, Garrett J.
Durgin, Tracy L.
Powers, Timothy S.
Zhu, Hong
Pavia, Michael R.
Published in Molecular Diversity. 1995, vol. 1, no. 1, p. 13-20
Abstract A series of analogous arrays of small, non-peptidyl, non-oligomeric compounds were synthesized on polystyrene resin. With the aid of a functionally differentiated phenolic scaffold, the batch preparation of unique benzamide and urea resins was accomplished, which were further derivatized in modified 96-well plates. An efficient cleavage reaction of the phenyl benzoate link enabled the isolation of more than 600 phenolic compounds in milligram quantities that were suitable for direct biological screening. The technology described herein represents a facile, economical approach to non-peptidyl chemical diversity.
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MEYERS, Harold V. et al. Multiple simultaneous synthesis of phenolic libraries. In: Molecular Diversity, 1995, vol. 1, n° 1, p. 13-20.

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