• Home
  1. Home
  2. Microarray-based functional protein profiling using peptide nucleic acid-encoded libraries
Scientific article
English

Microarray-based functional protein profiling using peptide nucleic acid-encoded libraries

Contributors

Winssinger, Nicolas; Harris, Jennifer L

Published in

Expert review of proteomics, vol. 2, no. 6, p. 937-947

Publication date

2005

Abstract

The availability of complete genome sequences from numerous organisms has provided investigators with the challenge of assigning physiologic functions to the encoded gene products. To facilitate this process, multiple technologies have been developed to profile the transcriptome and the proteome, including methods to monitor the function of enzymes in complex biologic systems. These methods typically target specific classes of enzymes and attempt to correlate the enzymatic activity with the specific phenotype of interest. Here, technologies to measure enzymatic activity on a subproteomic scale are reviewed, including the authors' own efforts, which are based on self-assembled microarrays utilizing peptide nucleic acid-encoded small-molecule libraries.

UNIGE affiliation entities

Not a UNIGE publication

Citation (ISO format)

WINSSINGER, Nicolas, HARRIS, Jennifer L. Microarray-based functional protein profiling using peptide nucleic acid-encoded libraries. In: Expert review of proteomics, 2005, vol. 2, n° 6, p. 937–947. doi: 10.1586/14789450.2.6.937

Identifiers

Journal ISSN

1478-9450
794views
0downloads

Technical informations

Creation

11/12/2012 17:06:00

First validation

11/12/2012 17:06:00

Update

13/10/2025 23:50:15

Status update

14/03/2023 19:54:17

Last indexation

01/07/2026 06:10:17
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated