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Title

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

Authors
Nikić, Ivana
Sorbara, Catherine
Brinkoetter, Mary
Bareyre, Florence M
Brück, Wolfgang
Bishop, Derron
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Published in Nature Medicine. 2011, vol. 17, no. 4, p. 495-9
Abstract In multiple sclerosis, a common inflammatory disease of the central nervous system, immune-mediated axon damage is responsible for permanent neurological deficits. How axon damage is initiated is not known. Here we use in vivo imaging to identify a previously undescribed variant of axon damage in a mouse model of multiple sclerosis. This process, termed 'focal axonal degeneration' (FAD), is characterized by sequential stages, beginning with focal swellings and progressing to axon fragmentation. Notably, most swollen axons persist unchanged for several days, and some recover spontaneously. Early stages of FAD can be observed in axons with intact myelin sheaths. Thus, contrary to the classical view, demyelination-a hallmark of multiple sclerosis-is not a prerequisite for axon damage. Instead, focal intra-axonal mitochondrial pathology is the earliest ultrastructural sign of damage, and it precedes changes in axon morphology. Molecular imaging and pharmacological experiments show that macrophage-derived reactive oxygen and nitrogen species (ROS and RNS) can trigger mitochondrial pathology and initiate FAD. Indeed, neutralization of ROS and RNS rescues axons that have already entered the degenerative process. Finally, axonal changes consistent with FAD can be detected in acute human multiple sclerosis lesions. In summary, our data suggest that inflammatory axon damage might be spontaneously reversible and thus a potential target for therapy.
Keywords AnimalsAxons/drug effects/immunology/pathologyEncephalomyelitis, Autoimmune, Experimental/drug therapy/immunology/pathologyFree Radical Scavengers/pharmacologyHumansMacrophage ActivationMiceMice, Inbred C57BLMice, TransgenicMicroglia/immunology/pathologyMicroscopy, Electron, TransmissionMicroscopy, VideoMultiple Sclerosis/pathologyMyelin Sheath/pathologyNerve Degeneration/pathologyOxidative StressReactive Nitrogen Species/antagonists & inhibitors/toxicityReactive Oxygen Species/antagonists & inhibitors/toxicity
Identifiers
PMID: 21441916
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Research group La Sclérose en plaques (908)
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NIKIĆ, Ivana et al. A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. In: Nature Medicine, 2011, vol. 17, n° 4, p. 495-9. https://archive-ouverte.unige.ch/unige:24999

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Deposited on : 2013-01-04

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