• Home
  1. Home
  2. Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle
Scientific article
English

Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle

ContributorsBouzakri, Karim; Plomgaard, Peter; Berney, Thierry; Donath, Marc Yves; Pedersen, Bente Karlund; Halban, Philippe A.
Published inDiabetes, vol. 60, no. 4, p. 1111-1121
Publication date2011
Abstract

Type 2 diabetes is characterized by insulin resistance with a relative deficiency in insulin secretion. This study explored the potential communication between insulin-resistant human skeletal muscle and primary (human and rat) β-cells.

Keywords
  • Animals
  • Apoptosis/drug effects
  • Cell Proliferation/drug effects
  • Cells, Cultured
  • Culture Media, Conditioned/metabolism/pharmacology
  • Cytokines/metabolism
  • Humans
  • In Situ Nick-End Labeling
  • Insulin/metabolism/secretion
  • Insulin Receptor Substrate Proteins/genetics
  • Insulin Resistance/physiology
  • Insulin-Secreting Cells/drug effects/metabolism
  • Male
  • Muscle Fibers, Skeletal/metabolism
  • Protein-Serine-Threonine Kinases/genetics/metabolism
  • RNA Interference
  • Rats
  • Rats, Wistar
  • Tumor Necrosis Factor-alpha/pharmacology
Affiliation entities
Research groups
Citation (ISO format)
BOUZAKRI, Karim et al. Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle. In: Diabetes, 2011, vol. 60, n° 4, p. 1111–1121. doi: 10.2337/db10-1178
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0012-1797
646views
2downloads

Technical informations

Creation24/10/2012 11:12:00
First validation24/10/2012 11:12:00
Update14/03/2023 17:49:03
Status update14/03/2023 17:49:03
Last indexation30/10/2024 08:11:24
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack