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Title

Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle

Authors
Plomgaard, Peter
Donath, Marc Yves
Pedersen, Bente Karlund
Published in Diabetes. 2011, vol. 60, no. 4, p. 1111-21
Abstract Type 2 diabetes is characterized by insulin resistance with a relative deficiency in insulin secretion. This study explored the potential communication between insulin-resistant human skeletal muscle and primary (human and rat) β-cells.
Keywords AnimalsApoptosis/drug effectsCell Proliferation/drug effectsCells, CulturedCulture Media, Conditioned/metabolism/pharmacologyCytokines/metabolismHumansIn Situ Nick-End LabelingInsulin/metabolism/secretionInsulin Receptor Substrate Proteins/geneticsInsulin Resistance/physiologyInsulin-Secreting Cells/drug effects/metabolismMaleMuscle Fibers, Skeletal/metabolismProtein-Serine-Threonine Kinases/genetics/metabolismRNA InterferenceRatsRats, WistarTumor Necrosis Factor-alpha/pharmacology
Identifiers
PMID: 21378173
Full text
Article (Published version) (2.8 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups La transplantation d'îlots de Langerhans (623)
Fonction de l'îlot de Langerhans (324)
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(ISO format)
BOUZAKRI, Karim et al. Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle. In: Diabetes, 2011, vol. 60, n° 4, p. 1111-21. https://archive-ouverte.unige.ch/unige:24937

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Deposited on : 2013-01-03

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