Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle

Bouzakri, Karim; Plomgaard, Peter; Berney, Thierry; Donath, Marc Yves; Pedersen, Bente Karlund; Halban, Philippe A.

doi:10.2337/db10-1178

Scientific article

English

Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle

ContributorsBouzakri, Karim; Plomgaard, Peter; Berney, Thierry; Donath, Marc Yves; Pedersen, Bente Karlund; Halban, Philippe A.

Published inDiabetes, vol. 60, no. 4, p. 1111-1121

Publication date2011

Abstract

Type 2 diabetes is characterized by insulin resistance with a relative deficiency in insulin secretion. This study explored the potential communication between insulin-resistant human skeletal muscle and primary (human and rat) β-cells.

Keywords

Animals
Apoptosis/drug effects
Cell Proliferation/drug effects
Cells, Cultured
Culture Media, Conditioned/metabolism/pharmacology
Cytokines/metabolism
Humans
In Situ Nick-End Labeling
Insulin/metabolism/secretion
Insulin Receptor Substrate Proteins/genetics
Insulin Resistance/physiology
Insulin-Secreting Cells/drug effects/metabolism
Male
Muscle Fibers, Skeletal/metabolism
Protein-Serine-Threonine Kinases/genetics/metabolism
RNA Interference
Rats
Rats, Wistar
Tumor Necrosis Factor-alpha/pharmacology

Affiliation

Research group

Citation (ISO format)

BOUZAKRI, Karim et al. Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle. In: Diabetes, 2011, vol. 60, n° 4, p. 1111–1121. doi: 10.2337/db10-1178

Article (Published version)

Identifiers

PID : unige:24937
DOI : 10.2337/db10-1178
PMID : 21378173

ISSN of the journal0012-1797

551views

2downloads

Creation10/24/2012 11:12:00 AM

First validation10/24/2012 11:12:00 AM

Update time03/14/2023 5:49:03 PM

Status update03/14/2023 5:49:03 PM

Last indexation10/18/2023 3:07:59 PM

Archive ouverte UNIGE

Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle

Type 2 diabetes is characterized by insulin resistance with a relative deficiency in insulin secretion. This study explored the potential communication between insulin-resistant human skeletal muscle and primary (human and rat) β-cells.

Technical informations