Rapamycin impairs proliferation of transplanted islet β cells

Niclauss, Nadja; Bosco, Domenico; Morel, Philippe; Giovannoni, Laurianne; Berney, Thierry; Parnaud, Géraldine

doi:10.1097/TP.0b013e31820c10c8

Scientific article

English

Rapamycin impairs proliferation of transplanted islet β cells

ContributorsNiclauss, Nadja; Bosco, Domenico; Morel, Philippe; Giovannoni, Laurianne; Berney, Thierry; Parnaud, Géraldine

Published inTransplantation, vol. 91, no. 7, p. 714-722

Publication date2011

Abstract

The cause for a progressive attrition of islet graft function observed over the years after islet transplantation is not well defined but may be in part the result of adverse effects of immunosuppressive agents. In this study, we examined the effect of rapamycin, a key component of the immunosuppressive regimen, on β-cell replication of transplanted islets.

Keywords

Animals
Cell Proliferation/drug effects
Cells, Cultured
Immunosuppressive Agents/pharmacology
Insulin/secretion
Insulin-Secreting Cells/drug effects/physiology
Islets of Langerhans Transplantation
Male
Rats
Rats, Sprague-Dawley
Signal Transduction/drug effects
Sirolimus/pharmacology

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

Citation (ISO format)

NICLAUSS, Nadja et al. Rapamycin impairs proliferation of transplanted islet β cells. In: Transplantation, 2011, vol. 91, n° 7, p. 714–722. doi: 10.1097/TP.0b013e31820c10c8

Article (Published version)

Identifiers

PID : unige:24905
DOI : 10.1097/TP.0b013e31820c10c8
PMID : 21297554

Journal ISSN0041-1337

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Rapamycin impairs proliferation of transplanted islet β cells

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