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Title

Rapamycin impairs proliferation of transplanted islet β cells

Authors
Giovannoni, Laurianne
Published in Transplantation. 2011, vol. 91, no. 7, p. 714-22
Abstract The cause for a progressive attrition of islet graft function observed over the years after islet transplantation is not well defined but may be in part the result of adverse effects of immunosuppressive agents. In this study, we examined the effect of rapamycin, a key component of the immunosuppressive regimen, on β-cell replication of transplanted islets.
Keywords AnimalsCell Proliferation/drug effectsCells, CulturedImmunosuppressive Agents/pharmacologyInsulin/secretionInsulin-Secreting Cells/drug effects/physiologyIslets of Langerhans TransplantationMaleRatsRats, Sprague-DawleySignal Transduction/drug effectsSirolimus/pharmacology
Identifiers
PMID: 21297554
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Article (Published version) (1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups La transplantation d'îlots de Langerhans (623)
Chirurgie viscérale (104)
Citation
(ISO format)
NICLAUSS, Nadja et al. Rapamycin impairs proliferation of transplanted islet β cells. In: Transplantation, 2011, vol. 91, n° 7, p. 714-22. https://archive-ouverte.unige.ch/unige:24905

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Deposited on : 2013-01-03

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