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Title

Developmental Stage-dependent persistent impact of propofol anesthesia on dendritic spines in the rat medial prefrontal cortex

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Published in Anesthesiology. 2011, vol. 115, no. 2, p. 282-93
Abstract Recent observations demonstrate that anesthetics rapidly impair synaptogenesis during neuronal circuitry development. Whether these effects are lasting and depend on the developmental stage at which these drugs are administered remains, however, to be explored.
Keywords Age FactorsAnesthesia, IntravenousAnesthetics, Intravenous/pharmacologyAnimalsDendritic Spines/drug effects/physiology/ultrastructureFemaleMaleMicroscopy, ElectronPrefrontal Cortex/drug effects/physiology/ultrastructurePropofol/pharmacologyRatsRats, WistarSynapses/drug effects/physiology
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PMID: 21701379
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Article (Published version) (4.5 MB) - public document Free access
Structures
Research groups Plasticité des synapses excitatrices (76)
Groupe Dayer Alexandre (Formation du circuit cortical) (875)
Anesthésie et neurosciences (883)
Project FNS: Molecular control of cortical circuits
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BRINER, Adrian et al. Developmental Stage-dependent persistent impact of propofol anesthesia on dendritic spines in the rat medial prefrontal cortex. In: Anesthesiology, 2011, vol. 115, n° 2, p. 282-93. https://archive-ouverte.unige.ch/unige:24789

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Deposited on : 2012-12-20

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