Scientific article
OA Policy
English

Developmental Stage-dependent persistent impact of propofol anesthesia on dendritic spines in the rat medial prefrontal cortex

Published inAnesthesiology, vol. 115, no. 2, p. 282-293
Publication date2011
Abstract

Recent observations demonstrate that anesthetics rapidly impair synaptogenesis during neuronal circuitry development. Whether these effects are lasting and depend on the developmental stage at which these drugs are administered remains, however, to be explored.

Keywords
  • Age Factors
  • Anesthesia, Intravenous
  • Anesthetics, Intravenous/pharmacology
  • Animals
  • Dendritic Spines/drug effects/physiology/ultrastructure
  • Female
  • Male
  • Microscopy, Electron
  • Prefrontal Cortex/drug effects/physiology/ultrastructure
  • Propofol/pharmacology
  • Rats
  • Rats, Wistar
  • Synapses/drug effects/physiology
Funding
  • Swiss National Science Foundation - Molecular control of cortical circuits
Citation (ISO format)
BRINER, Adrian et al. Developmental Stage-dependent persistent impact of propofol anesthesia on dendritic spines in the rat medial prefrontal cortex. In: Anesthesiology, 2011, vol. 115, n° 2, p. 282–293. doi: 10.1097/ALN.0b013e318221fbbd
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
Journal ISSN0003-3022
803views
666downloads

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Update13/10/2025 23:52:14
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