Developmental Stage-dependent persistent impact of propofol anesthesia on dendritic spines in the rat medial prefrontal cortex

Briner, Adrian; Nikonenko, Iryna; De Roo, Mathias; Dayer, Alexandre; Muller, Dominique; Vutskits, Laszlo

doi:10.1097/ALN.0b013e318221fbbd

Scientific article

Open access

English

Developmental Stage-dependent persistent impact of propofol anesthesia on dendritic spines in the rat medial prefrontal cortex

ContributorsBriner, Adrian; Nikonenko, Iryna; De Roo, Mathias; Dayer, Alexandre; Muller, Dominique; Vutskits, Laszlo

Published inAnesthesiology, vol. 115, no. 2, p. 282-293

Publication date2011

Abstract

Recent observations demonstrate that anesthetics rapidly impair synaptogenesis during neuronal circuitry development. Whether these effects are lasting and depend on the developmental stage at which these drugs are administered remains, however, to be explored.

Keywords

Age Factors
Anesthesia, Intravenous
Anesthetics, Intravenous/pharmacology
Animals
Dendritic Spines/drug effects/physiology/ultrastructure
Female
Male
Microscopy, Electron
Prefrontal Cortex/drug effects/physiology/ultrastructure
Propofol/pharmacology
Rats
Rats, Wistar
Synapses/drug effects/physiology

Affiliation

Research group

Funding

Swiss National Science Foundation - Molecular control of cortical circuits

Citation (ISO format)

BRINER, Adrian et al. Developmental Stage-dependent persistent impact of propofol anesthesia on dendritic spines in the rat medial prefrontal cortex. In: Anesthesiology, 2011, vol. 115, n° 2, p. 282–293. doi: 10.1097/ALN.0b013e318221fbbd

Article (Published version)

Identifiers

PID : unige:24789
DOI : 10.1097/ALN.0b013e318221fbbd
PMID : 21701379

ISSN of the journal0003-3022

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Developmental Stage-dependent persistent impact of propofol anesthesia on dendritic spines in the rat medial prefrontal cortex

Recent observations demonstrate that anesthetics rapidly impair synaptogenesis during neuronal circuitry development. Whether these effects are lasting and depend on the developmental stage at which these drugs are administered remains, however, to be explored.

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