UNIGE document Scientific Article
previous document  unige:24753  next document
add to browser collection

Démence vasculaire : les grands effets des petites lésions

Published in Revue médicale suisse. 2011, vol. 7, no. 316, p. 2190,2192-3
Abstract Vascular dementia due to multiple large strokes (multi-infarct dementia) is a well known entity. However, new clinicopathologic and neuroimaging data have highlighted the common occurrence of small vessel and microscopic vascular pathology in aging brains and recognized that vascular dementia due to small lesions is probably the most common form. In such cases, cortical microinfarcts are the strongest correlate of global cognitive function followed by basal ganglia and thalamic lacunes. Demyelination is only weekly associated with cognition and this relation is no longer significant after adjustement for the presence of lacunes. Awareness of the importance of small vascular lesions in brain aging, can improve diagnostic accuracy and help identify new targets, that could lead to novel therapeutic approaches in old age dementia.
Keywords Aging/pathologyBrain Infarction/pathologyDementia, Vascular/diagnosisDemyelinating Diseases/pathologyHumansMagnetic Resonance Imaging
PMID: 22164676
Full text
Article (Published version) (525 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive (577)
Groupe Bouras Constantin (neuropsychiatrie) (1)
(ISO format)
GOLD, Gabriel, KOVARI, Eniko Veronika. Démence vasculaire : les grands effets des petites lésions. In: Revue médicale suisse, 2011, vol. 7, n° 316, p. 2190,2192-3. https://archive-ouverte.unige.ch/unige:24753

235 hits

1 download


Deposited on : 2012-12-19

Export document
Format :
Citation style :