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Book chapter
English

Epothilones and Sarcodictyins: From Combinatorial Libraries to Designed Analogs

Published inAnticancer Agents: Frontiers in Cancer Chemotherapy, Editors Ojima, I.; Vite, G. D.; Altmann, K.-H., p. 148-170
PublisherAmerican Chemical Society
Collection
  • ACS Symposium Series; 796
Publication date2001
Abstract

The epothilones and sarcodictyins have shown to be potent cytotoxic compounds with a Taxol™-like mode of action. The clinical importance of Taxol™ has stimulated intense research into finding compounds with prospective superior chemotherapeutic properties to Taxol™. We have developed enabling synthetic technologies for the construction of combinatorial libraries of these two potentially important chemotherapeutics, which led, in both cases to compounds with superior biological activity.

Affiliation Not a UNIGE publication
Citation (ISO format)
WINSSINGER, Nicolas, NICOLAOU, K. C. Epothilones and Sarcodictyins: From Combinatorial Libraries to Designed Analogs. In: Anticancer Agents: Frontiers in Cancer Chemotherapy. [s.l.] : American Chemical Society, 2001. p. 148–170. (ACS Symposium Series) doi: 10.1021/bk-2001-0796.ch009
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Book chapter (Published version)
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Identifiers
ISBN9780841237452
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First validation12/11/2012 3:35:00 PM
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