Synthesis of a PNA-encoded cysteine protease inhibitor library

Debaene, François; Mejias, Lorenzo; Harris, Jennifer L.; Winssinger, Nicolas

doi:10.1016/j.tet.2004.05.107

Scientific article

English

Synthesis of a PNA-encoded cysteine protease inhibitor library

ContributorsDebaene, François; Mejias, Lorenzo; Harris, Jennifer L.; Winssinger, Nicolas

Published inTetrahedron, vol. 60, no. 39, p. 8677-8690

Publication date2004

Abstract

Peptide nucleic acids (PNAs) have been used to encode a combinatorial library whereby each compound is labeled with a PNA tag which reflects its synthetic history and localizes the compound upon hybridization to an oligonucleotide array. We report herein the full synthetic details for a 4000 member PNA-encoded library targeted towards cysteine protease.

Keywords

Microarrays
Combinatorial chemistry
Protease inhibitors
Peptide nucleic acid

Affiliation Not a UNIGE publication

Citation (ISO format)

DEBAENE, François et al. Synthesis of a PNA-encoded cysteine protease inhibitor library. In: Tetrahedron, 2004, vol. 60, n° 39, p. 8677–8690. doi: 10.1016/j.tet.2004.05.107

Article (Published version)

Identifiers

PID : unige:24737
DOI : 10.1016/j.tet.2004.05.107

Commercial URLhttp://linkinghub.elsevier.com/retrieve/pii/S0040402004008634

ISSN of the journal0040-4020

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Synthesis of a PNA-encoded cysteine protease inhibitor library

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