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Title

Synthesis of a PNA-encoded cysteine protease inhibitor library

Authors
Debaene, François
Mejias, Lorenzo
Harris, Jennifer L.
Published in Tetrahedron. 2004, vol. 60, no. 39, p. 8677-8690
Abstract Peptide nucleic acids (PNAs) have been used to encode a combinatorial library whereby each compound is labeled with a PNA tag which reflects its synthetic history and localizes the compound upon hybridization to an oligonucleotide array. We report herein the full synthetic details for a 4000 member PNA-encoded library targeted towards cysteine protease.
Keywords MicroarraysCombinatorial chemistryProtease inhibitorsPeptide nucleic acid
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DEBAENE, François et al. Synthesis of a PNA-encoded cysteine protease inhibitor library. In: Tetrahedron, 2004, vol. 60, n° 39, p. 8677-8690. https://archive-ouverte.unige.ch/unige:24737

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Deposited on : 2012-12-19

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