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Scientific article
English

Divergent Synthesis of a Pochonin Library Targeting HSP90 and In Vivo Efficacy of an Identified Inhibitor

Published inAngewandte Chemie, vol. 47, no. 23, p. 4432-4435
Publication date2008
Abstract

Make a clean breast of it: The generation of a library of pochonin D derivatives by a solid-phase approach has led to the discovery of pochoxime (see scheme), a potent inhibitor of the heat-shock protein 90, with over 100-fold improved incellular activity. Pochoxime was found to be effective in breast tumor xenografts, leading to a reduction in the tumor size.

Keywords
  • antitumor agents
  • bioorganic chemistry
  • natural products
  • solid-phase synthesis
  • synthesis design
Affiliation Not a UNIGE publication
Citation (ISO format)
BARLUENGA, Sofia et al. Divergent Synthesis of a Pochonin Library Targeting HSP90 and In Vivo Efficacy of an Identified Inhibitor. In: Angewandte Chemie, 2008, vol. 47, n° 23, p. 4432–4435. doi: 10.1002/anie.200800233
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Article (Published version)
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ISSN of the journal1433-7851
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