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Scientific Article
unige:24722 
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Resorcylic acid lactones: A pluripotent scaffold with therapeutic potential |
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| Authors | ||
| Published in | Comptes rendus chimie. 2008, vol. 11, no. 11-12, p. 1306-1317 | |
| Abstract | The recent discoveries of potent HSP90 and MAP kinase inhibitors amongst the resorcylic acid lactones (RALs) have revived interest in this family of natural products. Both HSP90 and MAP kinase inhibition hold tremendous therapeutic potential, particularly in the treatment of cancer. Our synthetic efforts towards the RALs and, in particular, selective inhibitors of HSP90 and kinases are reviewed. | |
| Keywords | Resorcylic acid lactones (RALs) — Kinase inhibitors — HSP90 — Total synthesis — Combinatorial synthesis — Solid-phase synthesis — Polymer supported reagents | |
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Article (Published version) (712 Kb) - Limited access to UNIGE Other version: http://linkinghub.elsevier.com/retrieve/pii/S163107480800101X |
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| Citation (ISO format) | BARLUENGA, Sofia et al. Resorcylic acid lactones: A pluripotent scaffold with therapeutic potential. In: Comptes rendus chimie, 2008, vol. 11, n° 11-12, p. 1306-1317. https://archive-ouverte.unige.ch/unige:24722 |
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