Scientific Article
previous document  unige:24721  next document
add to browser collection
Title

Synthesis of pochoxime prodrugs as potent HSP90 inhibitors

Authors
Wang, Cuihua
Barluenga, Sofia
Koripelly, Girish K.
Fontaine, Jean-Gonzague
Chen, Ruihong
Yu, Jin-Chen
Shen, Xiaodong
Chabala, John C.
show hidden authors show all authors [1 - 11]
Published in Bioorganic & Medicinal Chemistry Letters. 2009, vol. 19, no. 14, p. 3836-3840
Abstract Pochoximes are potent inhibitors of heat shock protein 90 (HSP90) based on the radicicol pharmacophores. Herein we present a pharmacokinetics and pharmacodynamics evaluation of this compound series as well as a phosphate prodrug strategy to facilitate formulation and improve oral bioavailability.
Keywords HSP90RadicicolPochoximeProdrug
Identifiers
Full text
Citation
(ISO format)
WANG, Cuihua et al. Synthesis of pochoxime prodrugs as potent HSP90 inhibitors. In: Bioorganic & Medicinal Chemistry Letters, 2009, vol. 19, n° 14, p. 3836-3840. https://archive-ouverte.unige.ch/unige:24721

180 hits

1 download

Update

Deposited on : 2012-12-18

Export document
Format :
Citation style :