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Synthesis of pochoxime prodrugs as potent HSP90 inhibitors

Wang, Cuihua
Barluenga, Sofia
Koripelly, Girish K.
Fontaine, Jean-Gonzague
Chen, Ruihong
Yu, Jin-Chen
Shen, Xiaodong
Chabala, John C.
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Published in Bioorganic & Medicinal Chemistry Letters. 2009, vol. 19, no. 14, p. 3836-3840
Abstract Pochoximes are potent inhibitors of heat shock protein 90 (HSP90) based on the radicicol pharmacophores. Herein we present a pharmacokinetics and pharmacodynamics evaluation of this compound series as well as a phosphate prodrug strategy to facilitate formulation and improve oral bioavailability.
Keywords HSP90RadicicolPochoximeProdrug
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WANG, Cuihua et al. Synthesis of pochoxime prodrugs as potent HSP90 inhibitors. In: Bioorganic & Medicinal Chemistry Letters, 2009, vol. 19, n° 14, p. 3836-3840. doi: 10.1016/j.bmcl.2009.04.030

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Deposited on : 2012-12-18

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