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Scientific article
English

DNA-Templated Homo- and Heterodimerization of Peptide Nucleic Acid Encoded Oligosaccharides that Mimick the Carbohydrate Epitope of HIV

Published inAngewandte Chemie, vol. 48, no. 41, p. 7695-7700
Publication date2009
Abstract

All under control: The programmability of hybridization has been utilized to generate a combinatorial library of structures that emulate the topologies of complex carbohydrates interacting with an antibody that shows broad-spectrum activity against HIV. This simple method involves attaching oligosaccharides tagged with peptide nucleic acids onto DNA templates in a controlled manner (see schematic picture).

Keywords
  • bioorganic chemistry
  • carbohydrates
  • DNA
  • HIV
  • peptide nucleic acids
Affiliation Not a UNIGE publication
Citation (ISO format)
GORSKA, Katarzyna et al. DNA-Templated Homo- and Heterodimerization of Peptide Nucleic Acid Encoded Oligosaccharides that Mimick the Carbohydrate Epitope of HIV. In: Angewandte Chemie, 2009, vol. 48, n° 41, p. 7695–7700. doi: 10.1002/anie.200903328
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ISSN of the journal1433-7851
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