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Title

Synthesis of a Resorcylic Acid Lactone (RAL) Library Using Fluorous-Mixture Synthesis and Profile of its Selectivity Against a Panel of Kinases

Authors
Jogireddy, Rajamalleswaramma
Dakas, Pierre-Yves
Valot, Gaëlle
Barluenga, Sofia
Published in Chemistry - A European Journal. 2009, vol. 15, no. 43, p. 11498-11506
Abstract A library of resorcylic acid lactones (RAL) containing a cis-enone moiety targeting kinases bearing a cysteine residue within the ATP-binding pocket was prepared using a fluorous-mixture synthesis and evaluated against a panel of 19 kinases thus providing important structure–activity trends. Two new analogues were then profiled for their selectivity against a panel of 402 kinases providing the broadest evaluation of this pharmacophores’ selectivity.
Keywords combinatorial chemistryfluorous chemistrykinaseslactonesresorcylic acid
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Article (Published version) (405 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://doi.wiley.com/10.1002/chem.200901375
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JOGIREDDY, Rajamalleswaramma et al. Synthesis of a Resorcylic Acid Lactone (RAL) Library Using Fluorous-Mixture Synthesis and Profile of its Selectivity Against a Panel of Kinases. In: Chemistry - A European Journal, 2009, vol. 15, n° 43, p. 11498-11506. https://archive-ouverte.unige.ch/unige:24714

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Deposited on : 2012-12-18

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