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Title

Molecular Editing of Kinase-Targeting Resorcylic Acid Lactones (RAL): Fluoroenone RAL

Authors
Jogireddy, Rajamalleswaramma
Barluenga, Sofia
Published in ChemMedChem. 2010, vol. 5, no. 5, p. 670-673
Abstract Molecular editing: The resorcylic acid lactones (RAL) are known small-molecule irreversible inhibitors of select kinases, and represent a unique pharmacophore with potential for further development in kinase research. The basic pharmacophore was “edited” to improve the properties and to diversify the scaffold. Two fluoroenones were synthesized, and their preliminary biological evaluation revealed interesting activity.
Keywords fluorineirreversible inhibitorskinasesresorcylic acid lactonesVEGF
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Article (Published version) (217 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://doi.wiley.com/10.1002/cmdc.201000047
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JOGIREDDY, Rajamalleswaramma, BARLUENGA, Sofia, WINSSINGER, Nicolas. Molecular Editing of Kinase-Targeting Resorcylic Acid Lactones (RAL): Fluoroenone RAL. In: ChemMedChem, 2010, vol. 5, n° 5, p. 670-673. https://archive-ouverte.unige.ch/unige:24705

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Deposited on : 2012-12-18

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