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Title

Ligand dimerization programmed by hybridization to study multimeric ligand–receptor interactions

Authors
Gorska, Katarzyna
Beyrath, Julien
Fournel, Sylvie
Guichard, Gilles
Published in Chemical Communications. 2010, vol. 46, no. 41, p. 7742-7744
Abstract Oligomerization of receptors induced or stabilized by polyvalent ligands is a fundamental mechanism in cellular recognition and signal transduction. Herein we report a general approach to encode complex peptide macrocycles with peptide nucleic acid (PNA) tags and program their oligomerization through hybridization as exemplified with a ligand binding to oligomeric DR5, a receptor of TRAIL cytokine.
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Other version: http://xlink.rsc.org/?DOI=c0cc02852e
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GORSKA, Katarzyna et al. Ligand dimerization programmed by hybridization to study multimeric ligand–receptor interactions. In: Chemical Communications, 2010, vol. 46, n° 41, p. 7742-7744. https://archive-ouverte.unige.ch/unige:24697

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Deposited on : 2012-12-18

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