Combinatorial Self-Assembly of Glycan Fragments into Microarrays

Huang, Kuo-Ting; Gorska, Katarzyna; Alvarez, Susana; Barluenga, Sofia; Winssinger, Nicolas

doi:10.1002/cbic.201000567

Scientific article

English

Combinatorial Self-Assembly of Glycan Fragments into Microarrays

Contributors

Huang, Kuo-Ting; Gorska, Katarzyna; Alvarez, Susana; Barluenga, Sofia; Winssinger, Nicolas

Published in

ChemBioChem, vol. 12, no. 1, p. 56-60

Publication date

2011

Abstract

Complex glycan arrays: A general method for preparing thioglycosides from native oligosaccharides and coupling them to peptide nucleic acids (PNAs) is reported. An array of 625 glycans was assembled by hybridization of two PNA-encoded libraries of 25 glycan fragments. The cooperativity of the fragment for carbohydrate binding proteins was validated with lectins of known specificity.

Keywords

glycan arrays
microarrays
PNA
self-assembly
thioglycosides

UNIGE affiliation entities

Not a UNIGE publication

Citation (ISO format)

HUANG, Kuo-Ting et al. Combinatorial Self-Assembly of Glycan Fragments into Microarrays. In: ChemBioChem, 2011, vol. 12, n° 1, p. 56–60. doi: 10.1002/cbic.201000567

Article (Published version)

Identifiers

PID : unige:24696
DOI : 10.1002/cbic.201000567

Journal ISSN

1439-4227

665views

2downloads

Creation

12/12/2012 10:14:00

First validation

12/12/2012 10:14:00

Update

13/10/2025 23:52:49

Status update

14/03/2023 17:47:41

Last indexation

01/07/2026 06:09:42

Combinatorial Self-Assembly of Glycan Fragments into Microarrays

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation