en
Scientific article
English

Combinatorial Self-Assembly of Glycan Fragments into Microarrays

Published inChemBioChem, vol. 12, no. 1, p. 56-60
Publication date2011
Abstract

Complex glycan arrays: A general method for preparing thioglycosides from native oligosaccharides and coupling them to peptide nucleic acids (PNAs) is reported. An array of 625 glycans was assembled by hybridization of two PNA-encoded libraries of 25 glycan fragments. The cooperativity of the fragment for carbohydrate binding proteins was validated with lectins of known specificity.

Keywords
  • glycan arrays
  • microarrays
  • PNA
  • self-assembly
  • thioglycosides
Affiliation Not a UNIGE publication
Citation (ISO format)
HUANG, Kuo-Ting et al. Combinatorial Self-Assembly of Glycan Fragments into Microarrays. In: ChemBioChem, 2011, vol. 12, n° 1, p. 56–60. doi: 10.1002/cbic.201000567
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Article (Published version)
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ISSN of the journal1439-4227
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