Combinatorial Self-Assembly of Glycan Fragments into Microarrays

Huang, Kuo-Ting; Gorska, Katarzyna; Alvarez, Susana; Barluenga, Sofia; Winssinger, Nicolas

doi:10.1002/cbic.201000567

Scientific article

English

Combinatorial Self-Assembly of Glycan Fragments into Microarrays

ContributorsHuang, Kuo-Ting; Gorska, Katarzyna; Alvarez, Susana; Barluenga, Sofia; Winssinger, Nicolas

Published inChemBioChem, vol. 12, no. 1, p. 56-60

Publication date2011

Abstract

Complex glycan arrays: A general method for preparing thioglycosides from native oligosaccharides and coupling them to peptide nucleic acids (PNAs) is reported. An array of 625 glycans was assembled by hybridization of two PNA-encoded libraries of 25 glycan fragments. The cooperativity of the fragment for carbohydrate binding proteins was validated with lectins of known specificity.

Keywords

glycan arrays
microarrays
PNA
self-assembly
thioglycosides

Affiliation Not a UNIGE publication

Citation (ISO format)

HUANG, Kuo-Ting et al. Combinatorial Self-Assembly of Glycan Fragments into Microarrays. In: ChemBioChem, 2011, vol. 12, n° 1, p. 56–60. doi: 10.1002/cbic.201000567

Article (Published version)

Identifiers

PID : unige:24696
DOI : 10.1002/cbic.201000567

ISSN of the journal1439-4227

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Combinatorial Self-Assembly of Glycan Fragments into Microarrays

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