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Combinatorial Self-Assembly of Glycan Fragments into Microarrays

Huang, Kuo-Ting
Gorska, Katarzyna
Alvarez, Susana
Barluenga, Sofia
Published in ChemBioChem. 2011, vol. 12, no. 1, p. 56-60
Abstract Complex glycan arrays: A general method for preparing thioglycosides from native oligosaccharides and coupling them to peptide nucleic acids (PNAs) is reported. An array of 625 glycans was assembled by hybridization of two PNA-encoded libraries of 25 glycan fragments. The cooperativity of the fragment for carbohydrate binding proteins was validated with lectins of known specificity.
Keywords glycan arraysmicroarraysPNAself-assemblythioglycosides
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HUANG, Kuo-Ting et al. Combinatorial Self-Assembly of Glycan Fragments into Microarrays. In: ChemBioChem, 2011, vol. 12, n° 1, p. 56-60.

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Deposited on : 2012-12-18

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