Scientific Article
previous document  unige:24676  next document
add to browser collection
Title

Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells

Authors
Ciobanu, Mihai
Huang, Kuo-Ting
Daguer, Jean-Pierre
Barluenga, Sofia
Schaeffer, Evelyne
Mueller, Christopher G.
Mitchell, Daniel A.
show hidden authors show all authors [1 - 9]
Published in Chemical Communications. 2011, vol. 47, no. 33, p. 9321-9323
Abstract We report the synthesis of a nucleic acid-encoded carbohydrate library, its combinatorial self-assembly into 37485 pairs and a screen against DC-SIGN leading to the identification of consensus ligand motifs. A prototypical example from the selected pairs was shown to have enhanced binding. A dendrimer incorporating the selected motifs inhibited gp120's binding to dendritic cells with higher efficiency than mannan.
Identifiers
Full text
Citation
(ISO format)
CIOBANU, Mihai et al. Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells. In: Chemical Communications, 2011, vol. 47, n° 33, p. 9321-9323. https://archive-ouverte.unige.ch/unige:24676

146 hits

254 downloads

Update

Deposited on : 2012-12-17

Export document
Format :
Citation style :