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Title

Nucleic Acid-Templated Energy Transfer Leading to a Photorelease Reaction and its Application to a System Displaying a Nonlinear Response

Authors
Röthlingshöfer, Manuel
Gorska, Katarzyna
Published in Journal of the American Chemical Society. 2011, vol. 133, no. 45, p. 18110-18113
Abstract The photocleavage of a nitrobenzyl-type linker (NPPOC) at 405 nm wavelength was enabled by nucleic acid-templated energy transfer from a sensitizer (thioxanthenone) to the linker. This strategy was used to release profluorescent rhodamine, which facilitated monitoring of the reaction via fluorescence measurement in a nonoverlapping window with the sensitizer/photocleavage reaction. The rate acceleration of the templated reaction was greater than 20-fold over the background reaction. The templated reaction was used in conjunction with strand displacement to design four-component systems that responded to an analyte (DNA). Programming a specific hierarchical relationship among the four components enabled the design of a system that responded first positively and then negatively to increasing levels of an analyte.
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Other version: http://pubs.acs.org/doi/abs/10.1021/ja2086504
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RÖTHLINGSHÖFER, Manuel, GORSKA, Katarzyna, WINSSINGER, Nicolas. Nucleic Acid-Templated Energy Transfer Leading to a Photorelease Reaction and its Application to a System Displaying a Nonlinear Response. In: Journal of the American Chemical Society, 2011, vol. 133, n° 45, p. 18110-18113. https://archive-ouverte.unige.ch/unige:24675

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Deposited on : 2012-12-17

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