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Title

Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries

Authors
Daguer, Jean-Pierre
Ciobanu, Mihai
Barluenga, Sofia
Published in Organic and Biomolecular Chemistry. 2012, vol. 10, no. 8, p. 1502-1505
Abstract Dehydrocholic acid was identified as a selective streptavidin binder from a PNA-tagged library. Isothermal calorimetry titration measurements showed this interaction to be entropically driven. Peptides tagged with dehydrocholic acid can be captured on a streptavidin resin and released under thermal conditions.
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Article (Published version) (1.5 MB) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://xlink.rsc.org/?DOI=c2ob06880j
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DAGUER, Jean-Pierre et al. Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries. In: Organic and Biomolecular Chemistry, 2012, vol. 10, n° 8, p. 1502-1505. https://archive-ouverte.unige.ch/unige:24671

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Deposited on : 2012-12-17

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