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Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis |
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Published in | Angewandte Chemie: International Edition. 2012, vol. 51, no. 22, p. 5391-5394 | |
Abstract | Natural selection: An acyclic chain containing an ene-yne-ene motif, in analogy to farnesyl diphosphate, was cyclized to obtain six distinct scaffolds using different transition-metal catalysts (see scheme). Notably, the guaianolide framework was accessed through enynene metathesis enabling the synthesis of three natural products. | |
Keywords | cyclization — diversity-oriented synthesis — metathesis — natural products — transition metals | |
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Citation (ISO format) | VALOT, Gaëlle et al. Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis. In: Angewandte Chemie: International Edition, 2012, vol. 51, n° 22, p. 5391-5394. doi: 10.1002/anie.201201157 https://archive-ouverte.unige.ch/unige:24670 |