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Scientific article
English

Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis

Contributors

Valot, Gaëlle; Garcia, José; Duplan, Vincent; Serba, Christelle; Barluenga, Sofia; Winssinger, Nicolas

Published in

Angewandte Chemie, vol. 51, no. 22, p. 5391-5394

Publication date

2012

Abstract

Natural selection: An acyclic chain containing an ene-yne-ene motif, in analogy to farnesyl diphosphate, was cyclized to obtain six distinct scaffolds using different transition-metal catalysts (see scheme). Notably, the guaianolide framework was accessed through enynene metathesis enabling the synthesis of three natural products.

Keywords

  • cyclization
  • diversity-oriented synthesis
  • metathesis
  • natural products
  • transition metals

UNIGE affiliation entities

Not a UNIGE publication

Citation (ISO format)

VALOT, Gaëlle et al. Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis. In: Angewandte Chemie, 2012, vol. 51, n° 22, p. 5391–5394. doi: 10.1002/anie.201201157

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1433-7851
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4downloads

Technical informations

Creation

12/12/2012 10:40:00

First validation

12/12/2012 10:40:00

Update

13/10/2025 23:52:59

Status update

14/03/2023 17:47:32

Last indexation

01/07/2026 06:09:29
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