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Title

Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis
Authors
Valot, Gaëlle
Garcia, José
Duplan, Vincent
Serba, Christelle
Barluenga, Sofia
Winssinger, Nicolas
Published in Angewandte Chemie: International Edition. 2012, vol. 51, no. 22, p. 5391-5394
Abstract Natural selection: An acyclic chain containing an ene-yne-ene motif, in analogy to farnesyl diphosphate, was cyclized to obtain six distinct scaffolds using different transition-metal catalysts (see scheme). Notably, the guaianolide framework was accessed through enynene metathesis enabling the synthesis of three natural products.
Keywords cyclization — diversity-oriented synthesis — metathesis — natural products — transition metals
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Article (Published version) (436 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://doi.wiley.com/10.1002/anie.201201157
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(ISO format) 		VALOT, Gaëlle et al. Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis. In: Angewandte Chemie: International Edition, 2012, vol. 51, n° 22, p. 5391-5394. https://archive-ouverte.unige.ch/unige:24670

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Deposited on : 2012-12-17

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