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Title

Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis

Authors
Valot, Gaëlle
Garcia, José
Duplan, Vincent
Barluenga, Sofia
Published in Angewandte Chemie. 2012, vol. 51, no. 22, p. 5391-5394
Abstract Natural selection: An acyclic chain containing an ene-yne-ene motif, in analogy to farnesyl diphosphate, was cyclized to obtain six distinct scaffolds using different transition-metal catalysts (see scheme). Notably, the guaianolide framework was accessed through enynene metathesis enabling the synthesis of three natural products.
Keywords cyclizationdiversity-oriented synthesismetathesisnatural productstransition metals
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VALOT, Gaëlle et al. Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis. In: Angewandte Chemie, 2012, vol. 51, n° 22, p. 5391-5394. doi: 10.1002/anie.201201157 https://archive-ouverte.unige.ch/unige:24670

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Deposited on : 2012-12-17

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