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Title

Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis

Authors
Valot, Gaëlle
Garcia, José
Duplan, Vincent
Barluenga, Sofia
Published in Angewandte Chemie: International Edition. 2012, vol. 51, no. 22, p. 5391-5394
Abstract Natural selection: An acyclic chain containing an ene-yne-ene motif, in analogy to farnesyl diphosphate, was cyclized to obtain six distinct scaffolds using different transition-metal catalysts (see scheme). Notably, the guaianolide framework was accessed through enynene metathesis enabling the synthesis of three natural products.
Keywords cyclizationdiversity-oriented synthesismetathesisnatural productstransition metals
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Article (Published version) (436 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://doi.wiley.com/10.1002/anie.201201157
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VALOT, Gaëlle et al. Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis. In: Angewandte Chemie: International Edition, 2012, vol. 51, n° 22, p. 5391-5394. https://archive-ouverte.unige.ch/unige:24670

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Deposited on : 2012-12-17

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