Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis

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Title		Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis
Authors		Valot, Gaëlle Garcia, José Duplan, Vincent Serba, Christelle Barluenga, Sofia Winssinger, Nicolas
Published in		Angewandte Chemie: International Edition. 2012, vol. 51, no. 22, p. 5391-5394
Abstract		Natural selection: An acyclic chain containing an ene-yne-ene motif, in analogy to farnesyl diphosphate, was cyclized to obtain six distinct scaffolds using different transition-metal catalysts (see scheme). Notably, the guaianolide framework was accessed through enynene metathesis enabling the synthesis of three natural products.
Keywords		cyclization — diversity-oriented synthesis — metathesis — natural products — transition metals
Identifiers		DOI: 10.1002/anie.201201157
Full text		Article (Published version) (436 Kb) - Limited access to UNIGE
Citation (ISO format)		VALOT, Gaëlle et al. Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis. In: Angewandte Chemie: International Edition, 2012, vol. 51, n° 22, p. 5391-5394. doi: 10.1002/anie.201201157 https://archive-ouverte.unige.ch/unige:24670

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Deposited on : 2012-12-17

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