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Applications of laser-polarized 129Xe to biomolecular assays

Lowery, Thomas J.
Rubin, Seth M.
Ruiz, E.Janette
Spence, Megan M.
Schultz, Peter G.
Pines, Alexander
Wemmer, David E.
Published in Magnetic Resonance Imaging. 2003, vol. 21, no. 10, p. 1235-1239
Abstract The chemical shift sensitivity and significant signal enhancement afforded by laser-polarized 129Xe have motivated the application of 129Xe NMR to biological imaging and spectroscopy. Recent research done by our group has used laser-polarized 129Xe in biomolecular assays that detect ligand-binding events and distinguish protein conformations. The successful application of unfunctionalized and functionalized 129Xe NMR to in vitro biomolecular assays suggests the potential future use of a functionalized xenon biosensor for in vivo imaging.
Keywords Xenon bindingLigand-protein interactionsBiosensorProtein conformation assay
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LOWERY, Thomas J. et al. Applications of laser-polarized 129Xe to biomolecular assays. In: Magnetic Resonance Imaging, 2003, vol. 21, n° 10, p. 1235-1239.

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Deposited on : 2012-12-12

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