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Scientific article
English

Applications of laser-polarized 129Xe to biomolecular assays

Published inMagnetic resonance imaging, vol. 21, no. 10, p. 1235-1239
Publication date2003
Abstract

The chemical shift sensitivity and significant signal enhancement afforded by laser-polarized 129Xe have motivated the application of 129Xe NMR to biological imaging and spectroscopy. Recent research done by our group has used laser-polarized 129Xe in biomolecular assays that detect ligand-binding events and distinguish protein conformations. The successful application of unfunctionalized and functionalized 129Xe NMR to in vitro biomolecular assays suggests the potential future use of a functionalized xenon biosensor for in vivo imaging.

Keywords
  • Xenon binding
  • Ligand-protein interactions
  • Biosensor
  • Protein conformation assay
Affiliation Not a UNIGE publication
Citation (ISO format)
LOWERY, Thomas J. et al. Applications of laser-polarized <sup>129</sup>Xe to biomolecular assays. In: Magnetic resonance imaging, 2003, vol. 21, n° 10, p. 1235–1239. doi: 10.1016/j.mri.2003.08.025
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Article (Published version)
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ISSN of the journal0730-725X
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