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Title

From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling

Authors
Harris, Jennifer L.
Backes, Bradley J.
Schultz, Peter G.
Published in Angewandte Chemie: International Edition. 2001, vol. 40, no. 17, p. 3152-3155
Abstract Small molecules encoded with peptidonucleic acid (PNA) were used to probe protein function in a microarray format. The PNA tag served to encode the synthetic history of the small molecule and to positionally encode the identity of the small molecule by its location upon hybridization to an oligonucleotide microarray (see picture).
Keywords combinatorial chemistrycysteine proteasefunctional genomicshydrolasessplit-pool synthesis
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WINSSINGER, Nicolas et al. From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling. In: Angewandte Chemie: International Edition, 2001, vol. 40, n° 17, p. 3152-3155. https://archive-ouverte.unige.ch/unige:24526

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Deposited on : 2012-12-12

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