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Modular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors |
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Published in | Angewandte Chemie. 2007, vol. 46, no. 36, p. 6899-6902 | |
Abstract | Short and sweet: A concise and modular synthesis of radicicol A and related resorcylic acid lactones using fluorous isolation technology and immobilized reagents is reported (see scheme, RF=C3H6C6F13, TMSE=2-(trimethylsilyl)ethyl). The compounds are found to be potent (low-nanomolar) inhibitors of selected kinases. Despite their irreversible inactivation of kinases, they show good selectivity amongst a panel of 127 kinases. | |
Keywords | inhibitors — resorcylic acid lactones — solid-phase extraction — total synthesis | |
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Citation (ISO format) | DAKAS, Pierre-Yves et al. Modular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors. In: Angewandte Chemie, 2007, vol. 46, n° 36, p. 6899-6902. doi: 10.1002/anie.200702406 https://archive-ouverte.unige.ch/unige:24521 |