Article (Published version) (259 Kb) - 
Limited access to UNIGE
Highlights
Home
Titles listModular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors
Titles listModular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors
Scientific Article
unige:24521 
 |
Modular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors |
|
| Authors | ||
| Published in | Angewandte Chemie. 2007, vol. 46, no. 36, p. 6899-6902 | |
| Abstract | Short and sweet: A concise and modular synthesis of radicicol A and related resorcylic acid lactones using fluorous isolation technology and immobilized reagents is reported (see scheme, RF=C3H6C6F13, TMSE=2-(trimethylsilyl)ethyl). The compounds are found to be potent (low-nanomolar) inhibitors of selected kinases. Despite their irreversible inactivation of kinases, they show good selectivity amongst a panel of 127 kinases. | |
| Keywords | inhibitors — resorcylic acid lactones — solid-phase extraction — total synthesis | |
| Identifiers | ||
| Full text | ||
| Citation (ISO format) | DAKAS, Pierre-Yves et al. Modular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors. In: Angewandte Chemie, 2007, vol. 46, n° 36, p. 6899-6902. doi: 10.1002/anie.200702406 https://archive-ouverte.unige.ch/unige:24521 |
513 hits 
1 download 
Contact an author
Update