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Title

Modular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors

Authors
Dakas, Pierre-Yves
Barluenga, Sofia
Totzke, Frank
Zirrgiebel, Ute
Published in Angewandte Chemie: International Edition. 2007, vol. 46, no. 36, p. 6899-6902
Abstract Short and sweet: A concise and modular synthesis of radicicol A and related resorcylic acid lactones using fluorous isolation technology and immobilized reagents is reported (see scheme, RF=C3H6C6F13, TMSE=2-(trimethylsilyl)ethyl). The compounds are found to be potent (low-nanomolar) inhibitors of selected kinases. Despite their irreversible inactivation of kinases, they show good selectivity amongst a panel of 127 kinases.
Keywords inhibitorsresorcylic acid lactonessolid-phase extractiontotal synthesis
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Article (Published version) (259 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://doi.wiley.com/10.1002/anie.200702406
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DAKAS, Pierre-Yves et al. Modular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors. In: Angewandte Chemie: International Edition, 2007, vol. 46, n° 36, p. 6899-6902. https://archive-ouverte.unige.ch/unige:24521

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Deposited on : 2012-12-12

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