Azidopeptide Nucleic Acid. An Alternative Strategy for Solid-Phase Peptide Nucleic Acid (PNA) Synthesis

Debaene, François; Winssinger, Nicolas

doi:10.1021/ol0358408

Scientific article

English

Azidopeptide Nucleic Acid. An Alternative Strategy for Solid-Phase Peptide Nucleic Acid (PNA) Synthesis

ContributorsDebaene, François; Winssinger, Nicolas

Published inOrganic letters, vol. 5, no. 23, p. 4445-4447

Publication date2003

Abstract

A practical and efficient method for PNA synthesis using an azide group to mask the N-terminus is reported. The deprotection was carried out in 5 min, while couplings were complete within 60 min. The near neutral conditions of the phosphine deprotection combined with the base-free coupling using hydroxybenzotriazole-activated monomers make this approach very mild.

Affiliation entities

Not a UNIGE publication

Citation (ISO format)

DEBAENE, François, WINSSINGER, Nicolas. Azidopeptide Nucleic Acid. An Alternative Strategy for Solid-Phase Peptide Nucleic Acid (PNA) Synthesis. In: Organic letters, 2003, vol. 5, n° 23, p. 4445–4447. doi: 10.1021/ol0358408

Article (Published version)

Identifiers

PID : unige:24519
DOI : 10.1021/ol0358408

Journal ISSN1523-7052

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Azidopeptide Nucleic Acid. An Alternative Strategy for Solid-Phase Peptide Nucleic Acid (PNA) Synthesis

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