Azidopeptide Nucleic Acid. An Alternative Strategy for Solid-Phase Peptide Nucleic Acid (PNA) Synthesis

Debaene, François; Winssinger, Nicolas

doi:10.1021/ol0358408

Scientific article

English

Azidopeptide Nucleic Acid. An Alternative Strategy for Solid-Phase Peptide Nucleic Acid (PNA) Synthesis

Contributors

Debaene, François; Winssinger, Nicolas

Published in

Organic letters, vol. 5, no. 23, p. 4445-4447

Publication date

2003

Abstract

A practical and efficient method for PNA synthesis using an azide group to mask the N-terminus is reported. The deprotection was carried out in 5 min, while couplings were complete within 60 min. The near neutral conditions of the phosphine deprotection combined with the base-free coupling using hydroxybenzotriazole-activated monomers make this approach very mild.

UNIGE affiliation entities

Not a UNIGE publication

Citation (ISO format)

DEBAENE, François, WINSSINGER, Nicolas. Azidopeptide Nucleic Acid. An Alternative Strategy for Solid-Phase Peptide Nucleic Acid (PNA) Synthesis. In: Organic letters, 2003, vol. 5, n° 23, p. 4445–4447. doi: 10.1021/ol0358408

Article (Published version)

Identifiers

PID : unige:24519
DOI : 10.1021/ol0358408

Journal ISSN

1523-7052

638views

2downloads

Creation

11/12/2012 16:38:00

First validation

11/12/2012 16:38:00

Update

13/10/2025 23:53:13

Status update

14/03/2023 17:47:11

Last indexation

01/07/2026 06:09:12

Azidopeptide Nucleic Acid. An Alternative Strategy for Solid-Phase Peptide Nucleic Acid (PNA) Synthesis

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation