Scientific Article
previous document  unige:24512  next document
add to browser collection
Title

Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective Against Vancomycin-Resistant Bacteria

Authors
Nicolaou, K. C.
Hughes, Robert
Cho, Suk Young
Smethurst, Christian
Labischinski, Harald
Endermann, Rainer
Published in Angewandte Chemie: International Edition. 2000, vol. 39, no. 21, p. 3823-3828
Abstract Biological activity can be predicted at a prescreening stage by using a target-accelerated combinatorial synthesis. The rate of dimerization of vancomycin analogues (see picture, X=CH=CH2, SAc) in the presence of vancomycin's targets Ac-d-Ala-d-Ala and Ac2-l-Lys-d-Ala-d-Ala correlated well with the observed biological activity. From this study three highly potent antibacterial agents effective against both vancomycin-susceptible and vancomycin-resistant bacteria strains were identified.
Keywords antibioticscombinatorial chemistrydrug researchdrug-resistant bacteriavancomycin
Identifiers
Full text
Citation
(ISO format)
NICOLAOU, K. C. et al. Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective Against Vancomycin-Resistant Bacteria. In: Angewandte Chemie: International Edition, 2000, vol. 39, n° 21, p. 3823-3828. https://archive-ouverte.unige.ch/unige:24512

200 hits

1 download

Update

Deposited on : 2012-12-12

Export document
Format :
Citation style :