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Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics

Nicolaou, K. C.
Boddy, Christopher N. C.
Bräse, Stefan
Published in Angewandte Chemie: International Edition. 1999, vol. 38, no. 15, p. 2096-2152
Abstract The war against infectious bacteria is not over! Although vancomycin and glycopeptide antibiotics have provided a strong last line of defence against many drug-resistant bacteria, their overuse has given rise to more dangerous strains of bacteria. An understanding of the chemistry and biology of these highly complex glycopeptides are destined to play a crucial role in the discovery of new antibiotics.
Keywords BiarylsGlycopeptidesMode of actionTotal synthesisVancomycin
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NICOLAOU, K. C. et al. Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics. In: Angewandte Chemie: International Edition, 1999, vol. 38, n° 15, p. 2096-2152.

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Deposited on : 2012-12-12

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