Concise Synthesis of Pochonin A, an HSP90 Inhibitor

Moulin, Emilie; Barluenga, Sofia; Winssinger, Nicolas

doi:10.1021/ol052263+

Scientific article

English

Concise Synthesis of Pochonin A, an HSP90 Inhibitor

ContributorsMoulin, Emilie; Barluenga, Sofia; Winssinger, Nicolas

Published inOrganic letters, vol. 7, no. 25, p. 5637-5639

Publication date2005

Abstract

An expedient synthesis of (−)-pochonin A is reported (seven steps). This natural product is closely related to radicicol and was shown to be a 90 nM inhibitor of HSP90.

Affiliation entities

Not a UNIGE publication

Citation (ISO format)

MOULIN, Emilie, BARLUENGA, Sofia, WINSSINGER, Nicolas. Concise Synthesis of Pochonin A, an HSP90 Inhibitor. In: Organic letters, 2005, vol. 7, n° 25, p. 5637–5639. doi: 10.1021/ol052263+

Article (Published version)

Identifiers

PID : unige:24507
DOI : 10.1021/ol052263+

Journal ISSN1523-7052

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Update13/10/2025 23:53:18

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Concise Synthesis of Pochonin A, an HSP90 Inhibitor

An expedient synthesis of (−)-pochonin A is reported (seven steps). This natural product is closely related to radicicol and was shown to be a 90 nM inhibitor of HSP90.

Technical informations