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Title

Expanding the scope of PNA-encoded libraries: divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases

Authors
Debaene, François
Da Silva, Julien A.
Pianowski, Zbigniew
Duran, Fernando J.
Published in Tetrahedron. 2007, vol. 63, no. 28, p. 6577-6586
Abstract Seven PNA-encoded combinatorial libraries targeting proteases and phosphatases with covalent reversible and irreversible mechanism-based inhibitors were prepared. The libraries were synthesized using modified PNA monomers, which dramatically increase the water solubility of the libraries in biologically relevant buffers. The libraries were shown to selectively inhibit targeted enzymes.
Keywords PNAProtease inhibitorsPhosphatase inhibitorsCombinatorial chemistryMicroarrays
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DEBAENE, François et al. Expanding the scope of PNA-encoded libraries: divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases. In: Tetrahedron, 2007, vol. 63, n° 28, p. 6577-6586. https://archive-ouverte.unige.ch/unige:24503

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Deposited on : 2012-12-12

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