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Title

New Selenium-Based Safety-Catch Linkers: Solid-Phase Semisynthesis of Vancomycin

Authors
Nicolaou, K. C.
Hughes, Robert
Smethurst, Christopher
Cho, Suk Young
Published in Angewandte Chemie: International Edition. 2000, vol. 39, no. 6, p. 1084-1088
Abstract Pro-allyl and pro-alloc linkers can be formed by alkylation or esterification of a selenium-bound resin (the example shown is for the formation of a polymer-bound pro-allyl derivative) and can be readily cleaved in excellent yields under mild conditions. The scope of the pro-allyl linker has been demonstrated with the solid-phase semisynthesis of vancomycin. Alloc=allyloxycarbonyl.
Keywords antibioticsnatural productsseleniumsolid-phase synthesisvancomycin
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NICOLAOU, K. C. et al. New Selenium-Based Safety-Catch Linkers: Solid-Phase Semisynthesis of Vancomycin. In: Angewandte Chemie: International Edition, 2000, vol. 39, n° 6, p. 1084-1088. https://archive-ouverte.unige.ch/unige:24501

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Deposited on : 2012-12-12

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