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Chemistry and biology of resorcylic acid lactones

Barluenga, Sofia
Published in Chemical Communications. 2007, no. 1, p. 22-36
Abstract While resorcylic acid lactones (RALs) have been known for a long time, the more recent discoveries that radicicol is a potent and selective HSP90 inhibitor while other members such as hypothemycin, LL-Z1640-2 and LL-783,277 are potent kinase inhibitors have stimulated a renewed interest in this family of natural products. The recent developments regarding the chemistry and biology of RALs are reviewed.
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WINSSINGER, Nicolas, BARLUENGA, Sofia. Chemistry and biology of resorcylic acid lactones. In: Chemical Communications, 2007, n° 1, p. 22-36.

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Deposited on : 2012-12-12

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