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Title

Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol-Resistant Tumor Cells

Authors
Nicolaou, K. C.
Vourloumis, Dionisios
Li, Tianhu
Pastor, Joaquin
He, Yun
Ninkovic, Sacha
Sarabia, Francisco
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Published in Angewandte Chemie: International Edition. 1997, vol. 36, no. 19, p. 2097-2103
Abstract A library of epothilone A and B analogues, which was constructed by solid-phase combinatorial synthesis using SMART Microreactors and solution chemistry, was screened in two different tubulin binding assays. Selected compounds were subjected to cytotoxicity studies against a number of cell lines, including Taxol-resistant cells. Important structure–activity relationship emerged from these studies, which sets the stage for further discoveries and developments in the anticancer field.
Keywords antitumor agentscombinatorial chemistryepothilonesmicroreactorsstructure–activity relationships
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Other version: http://doi.wiley.com/10.1002/anie.199720971
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NICOLAOU, K. C. et al. Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol-Resistant Tumor Cells. In: Angewandte Chemie: International Edition, 1997, vol. 36, n° 19, p. 2097-2103. https://archive-ouverte.unige.ch/unige:24442

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Deposited on : 2012-12-12

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