Synthesis of epothilones A and B in solid and solution phase

Nicolaou, K. C.; Winssinger, Nicolas; Pastor, J.; Ninkovic, S.; Sarabia, F.; He, Y.; Vourloumis, D.; Yang, Z.; Li, T.; Giannakakou, P.; Hamel, E.

doi:10.1038/387268a0

Scientific article

English

Synthesis of epothilones A and B in solid and solution phase

ContributorsNicolaou, K. C.; Winssinger, Nicolas; Pastor, J.; Ninkovic, S.; Sarabia, F.; He, Y.; Vourloumis, D.; Yang, Z.; Li, T.; Giannakakou, P.; Hamel, E.

Published inNature, vol. 387, no. 6630, p. 268-272

Publication date1997

Abstract

Epothilones A and B, two compounds that have been recently isolated from myxobacterium Sorangium cellulosum strain 90, have generated intense interest among chemists, biologists and clinicians owing to the structural complexity, unusual mechanism of interaction with microtubules and anticancer potential of these molecules.

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Citation (ISO format)

NICOLAOU, K. C. et al. Synthesis of epothilones A and B in solid and solution phase. In: Nature, 1997, vol. 387, n° 6630, p. 268–272. doi: 10.1038/387268a0

Article (Published version)

Identifiers

PID : unige:24440
DOI : 10.1038/387268a0

Journal ISSN0028-0836

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Synthesis of epothilones A and B in solid and solution phase

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