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Scientific article
English

A General and Highly Efficient Solid Phase Synthesis of Oligosaccharides. Total Synthesis of a Heptasaccharide Phytoalexin Elicitor (HPE)

Published inJournal of the American Chemical Society, vol. 119, no. 2, p. 449-450
Publication date1997
Abstract

A new solid phase method for the synthesis of complex oligosaccharides is described. The method involves attachment to phenolic polystyrene of the first carbohydrate unit, through its anomeric position and via a photolabile linker, using dimethylthiomethylsulfonium triflate as an activator. Reiteration of the glycosidation process allows stereocontrolled growth of linear or branched oligosaccharides in high yield. Cleavage from the resin is efficiently achieved photolytically. The application of the method to the total prepn. of the heptasaccharide phytoalexin elicitor (HPE) is described.

Affiliation Not a UNIGE publication
Citation (ISO format)
NICOLAOU, K. C. et al. A General and Highly Efficient Solid Phase Synthesis of Oligosaccharides. Total Synthesis of a Heptasaccharide Phytoalexin Elicitor (HPE). In: Journal of the American Chemical Society, 1997, vol. 119, n° 2, p. 449–450. doi: 10.1021/ja963482g
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ISSN of the journal0002-7863
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