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Scientific article
English

Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold

Published inAngewandte Chemie, vol. 45, no. 24, p. 3951-3954
Publication date2006
Abstract

On solid ground: Despite no obvious resemblance to adenosine analogues, the family of resorcyclic macrolides contains a high proportion of kinase and ATPase inhibitors. A solid-phase total synthesis of aigialomycin D extends the diversity of this class of natural product. Aigialomycin was found to inhibit CDK1/5 and GSK. EOM=ethoxymethyl.

Keywords
  • natural products
  • protein kinase inhibitors
  • solid-phase synthesis
  • total synthesis
Affiliation Not a UNIGE publication
Citation (ISO format)
BARLUENGA, Sofia et al. Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold. In: Angewandte Chemie, 2006, vol. 45, n° 24, p. 3951–3954. doi: 10.1002/anie.200600593
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1433-7851
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