Article (Published version) (205 Kb) - 
Limited access to UNIGEOther version: http://doi.wiley.com/10.1002/anie.200600593
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Scientific Article
unige:24437 
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Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold |
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| Published in | Angewandte Chemie: International Edition. 2006, vol. 45, no. 24, p. 3951-3954 | |
| Abstract | On solid ground: Despite no obvious resemblance to adenosine analogues, the family of resorcyclic macrolides contains a high proportion of kinase and ATPase inhibitors. A solid-phase total synthesis of aigialomycin D extends the diversity of this class of natural product. Aigialomycin was found to inhibit CDK1/5 and GSK. EOM=ethoxymethyl. | |
| Keywords | natural products — protein kinase inhibitors — solid-phase synthesis — total synthesis | |
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| Full text |
Article (Published version) (205 Kb) - Limited access to UNIGE Other version: http://doi.wiley.com/10.1002/anie.200600593 |
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| Citation (ISO format) | BARLUENGA, Sofia et al. Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold. In: Angewandte Chemie: International Edition, 2006, vol. 45, n° 24, p. 3951-3954. https://archive-ouverte.unige.ch/unige:24437 |
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