Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold

Barluenga, Sofia; Dakas, Pierre-Yves; Ferandin, Yoan; Meijer, Laurent; Winssinger, Nicolas

doi:10.1002/anie.200600593

Scientific article

English

Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold

ContributorsBarluenga, Sofia; Dakas, Pierre-Yves; Ferandin, Yoan; Meijer, Laurent; Winssinger, Nicolas

Published inAngewandte Chemie, vol. 45, no. 24, p. 3951-3954

Publication date2006

Abstract

On solid ground: Despite no obvious resemblance to adenosine analogues, the family of resorcyclic macrolides contains a high proportion of kinase and ATPase inhibitors. A solid-phase total synthesis of aigialomycin D extends the diversity of this class of natural product. Aigialomycin was found to inhibit CDK1/5 and GSK. EOM=ethoxymethyl.

Keywords

natural products
protein kinase inhibitors
solid-phase synthesis
total synthesis

Affiliation entities

Not a UNIGE publication

Citation (ISO format)

BARLUENGA, Sofia et al. Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold. In: Angewandte Chemie, 2006, vol. 45, n° 24, p. 3951–3954. doi: 10.1002/anie.200600593

Article (Published version)

Identifiers

PID : unige:24437
DOI : 10.1002/anie.200600593

Journal ISSN1433-7851

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Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold

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