Scientific article

Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold

Published inAngewandte Chemie, vol. 45, no. 24, p. 3951-3954
Publication date2006

On solid ground: Despite no obvious resemblance to adenosine analogues, the family of resorcyclic macrolides contains a high proportion of kinase and ATPase inhibitors. A solid-phase total synthesis of aigialomycin D extends the diversity of this class of natural product. Aigialomycin was found to inhibit CDK1/5 and GSK. EOM=ethoxymethyl.

  • natural products
  • protein kinase inhibitors
  • solid-phase synthesis
  • total synthesis
Affiliation Not a UNIGE publication
Citation (ISO format)
BARLUENGA, Sofia et al. Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold. In: Angewandte Chemie, 2006, vol. 45, n° 24, p. 3951–3954. doi: 10.1002/anie.200600593
Main files (1)
Article (Published version)
ISSN of the journal1433-7851

Technical informations

Creation12/11/2012 5:11:00 PM
First validation12/11/2012 5:11:00 PM
Update time03/14/2023 5:46:53 PM
Status update03/14/2023 5:46:52 PM
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