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Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold

Barluenga, Sofia
Dakas, Pierre-Yves
Ferandin, Yoan
Meijer, Laurent
Published in Angewandte Chemie: International Edition. 2006, vol. 45, no. 24, p. 3951-3954
Abstract On solid ground: Despite no obvious resemblance to adenosine analogues, the family of resorcyclic macrolides contains a high proportion of kinase and ATPase inhibitors. A solid-phase total synthesis of aigialomycin D extends the diversity of this class of natural product. Aigialomycin was found to inhibit CDK1/5 and GSK. EOM=ethoxymethyl.
Keywords natural productsprotein kinase inhibitorssolid-phase synthesistotal synthesis
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BARLUENGA, Sofia et al. Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold. In: Angewandte Chemie: International Edition, 2006, vol. 45, n° 24, p. 3951-3954.

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Deposited on : 2012-12-12

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