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Title

A key role for NOX4 in epithelial cell death during development of lung fibrosis

Authors
Deffert, Christine
Arbiser, Jack L
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Published in Antioxidants and Redox Signaling. 2011, vol. 15, no. 3, p. 607-19
Abstract The pathogenesis of pulmonary fibrosis is linked to oxidative stress, possibly generated by the reactive oxygen species (ROS) generating NADPH oxidase NOX4. Epithelial cell death is a crucial early step in the development of the disease, followed only later by the fibrotic stage. We demonstrate that in lungs of patients with idiopathic lung fibrosis, there is strong expression of NOX4 in hyperplastic alveolar type II cells.
Keywords AnimalsApoptosis/drug effects/geneticsBleomycin/pharmacologyCells, CulturedGene ExpressionIdiopathic Pulmonary Fibrosis/genetics/metabolism/pathologyMaleMiceNADPH Oxidase/antagonists & inhibitors/genetics/metabolismOxidative Stress/geneticsPulmonary Alveoli/drug effects/metabolism/pathologyRNA, Small Interfering/geneticsReactive Oxygen Species/metabolismRespiratory Mucosa/metabolism/pathologySmad2 Protein/metabolismTransforming Growth Factor beta1/metabolism
Identifiers
PMID: 21391892
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Structures
Research groups Groupe Pache Jean-Claude (pathologie clinique) (658)
Facteurs influençants le développement pulmonaire: étude translationnelle chez l'animal et l'homme (182)
Radicaux libres et cellules souches embryonnaires (60)
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CARNESECCHI, Stéphanie et al. A key role for NOX4 in epithelial cell death during development of lung fibrosis. In: Antioxidants and Redox Signaling, 2011, vol. 15, n° 3, p. 607-19. https://archive-ouverte.unige.ch/unige:24267

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Deposited on : 2012-11-30

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