en
Scientific article
English

A key role for NOX4 in epithelial cell death during development of lung fibrosis

Published inAntioxidants & redox signaling, vol. 15, no. 3, p. 607-619
Publication date2011
Abstract

The pathogenesis of pulmonary fibrosis is linked to oxidative stress, possibly generated by the reactive oxygen species (ROS) generating NADPH oxidase NOX4. Epithelial cell death is a crucial early step in the development of the disease, followed only later by the fibrotic stage. We demonstrate that in lungs of patients with idiopathic lung fibrosis, there is strong expression of NOX4 in hyperplastic alveolar type II cells.

Keywords
  • Animals
  • Apoptosis/drug effects/genetics
  • Bleomycin/pharmacology
  • Cells, Cultured
  • Gene Expression
  • Idiopathic Pulmonary Fibrosis/genetics/metabolism/pathology
  • Male
  • Mice
  • NADPH Oxidase/antagonists & inhibitors/genetics/metabolism
  • Oxidative Stress/genetics
  • Pulmonary Alveoli/drug effects/metabolism/pathology
  • RNA, Small Interfering/genetics
  • Reactive Oxygen Species/metabolism
  • Respiratory Mucosa/metabolism/pathology
  • Smad2 Protein/metabolism
  • Transforming Growth Factor beta1/metabolism
Citation (ISO format)
CARNESECCHI, Stéphanie et al. A key role for NOX4 in epithelial cell death during development of lung fibrosis. In: Antioxidants & redox signaling, 2011, vol. 15, n° 3, p. 607–619. doi: 10.1089/ars.2010.3829
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1523-0864
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5downloads

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