A key role for NOX4 in epithelial cell death during development of lung fibrosis

Carnesecchi, Stéphanie; Deffert, Christine; Donati, Yves Richard; Basset, Olivier; Hinz, Boris; Preynat-Seauve, Olivier; Guichard, Cécile; Arbiser, Jack L; Banfi, Botond; Pache, Jean-Claude; Barazzone, Constance; Krause, Karl-Heinz

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Title		A key role for NOX4 in epithelial cell death during development of lung fibrosis
Authors		Carnesecchi, Stéphanie Deffert, Christine Donati, Yves Richard Basset, Olivier Hinz, Boris Preynat-Seauve, Olivier Guichard, Cécile Arbiser, Jack L Banfi, Botond Pache, Jean-Claude Barazzone, Constance Krause, Karl-Heinz show all authors [1 - 12]
Published in		Antioxidants and Redox Signaling. 2011, vol. 15, no. 3, p. 607-19
Abstract		The pathogenesis of pulmonary fibrosis is linked to oxidative stress, possibly generated by the reactive oxygen species (ROS) generating NADPH oxidase NOX4. Epithelial cell death is a crucial early step in the development of the disease, followed only later by the fibrotic stage. We demonstrate that in lungs of patients with idiopathic lung fibrosis, there is strong expression of NOX4 in hyperplastic alveolar type II cells.
Keywords		Animals — Apoptosis/drug effects/genetics — Bleomycin/pharmacology — Cells, Cultured — Gene Expression — Idiopathic Pulmonary Fibrosis/genetics/metabolism/pathology — Male — Mice — NADPH Oxidase/antagonists & inhibitors/genetics/metabolism — Oxidative Stress/genetics — Pulmonary Alveoli/drug effects/metabolism/pathology — RNA, Small Interfering/genetics — Reactive Oxygen Species/metabolism — Respiratory Mucosa/metabolism/pathology — Smad2 Protein/metabolism — Transforming Growth Factor beta1/metabolism
Identifiers		DOI: 10.1089/ars.2010.3829 PMID: 21391892
Full text		Article (Published version) (1.2 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de pédiatrie
Research groups		Groupe Pache Jean-Claude (pathologie clinique) (658) Facteurs influençants le développement pulmonaire: étude translationnelle chez l'animal et l'homme (182) Radicaux libres et cellules souches embryonnaires (60)
Citation (ISO format)		CARNESECCHI, Stéphanie et al. A key role for NOX4 in epithelial cell death during development of lung fibrosis. In: Antioxidants and Redox Signaling, 2011, vol. 15, n° 3, p. 607-19. https://archive-ouverte.unige.ch/unige:24267