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A key role for NOX4 in epithelial cell death during development of lung fibrosis |
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Published in | Antioxidants & Redox Signaling. 2011, vol. 15, no. 3, p. 607-19 | |
Abstract | The pathogenesis of pulmonary fibrosis is linked to oxidative stress, possibly generated by the reactive oxygen species (ROS) generating NADPH oxidase NOX4. Epithelial cell death is a crucial early step in the development of the disease, followed only later by the fibrotic stage. We demonstrate that in lungs of patients with idiopathic lung fibrosis, there is strong expression of NOX4 in hyperplastic alveolar type II cells. | |
Keywords | Animals — Apoptosis/drug effects/genetics — Bleomycin/pharmacology — Cells, Cultured — Gene Expression — Idiopathic Pulmonary Fibrosis/genetics/metabolism/pathology — Male — Mice — NADPH Oxidase/antagonists & inhibitors/genetics/metabolism — Oxidative Stress/genetics — Pulmonary Alveoli/drug effects/metabolism/pathology — RNA, Small Interfering/genetics — Reactive Oxygen Species/metabolism — Respiratory Mucosa/metabolism/pathology — Smad2 Protein/metabolism — Transforming Growth Factor beta1/metabolism | |
Identifiers | PMID: 21391892 | |
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Research groups | Facteurs influençants le développement pulmonaire: étude translationnelle chez l'animal et l'homme (182) Groupe Pache Jean-Claude (pathologie clinique) (658) Radicaux libres et cellules souches embryonnaires (60) | |
Citation (ISO format) | CARNESECCHI, Stéphanie et al. A key role for NOX4 in epithelial cell death during development of lung fibrosis. In: Antioxidants & redox signaling, 2011, vol. 15, n° 3, p. 607-19. doi: 10.1089/ars.2010.3829 https://archive-ouverte.unige.ch/unige:24267 |