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Sendai virus induced cytoplasmic actin remodeling correlates with efficient virus particle production

Published in Virology. 2011, vol. 410, no. 1, p. 7-16
Abstract Cytoplasmic actins have been found interacting with viral proteins and identified in virus particles. We analyzed by confocal microscopy the cytoplasmic β- and γ-actin patterns during the course of Sendai virus infections in polarized cells. We observed a spectacular remodeling of the β-cytoplasmic actin which correlated with productive viral multiplication. Conversely, suppression of M during the course of a productive infection resulted in the decrease of particle production and the absence of β-actin remodeling. As concomitant suppression of β- and γ-actins resulted as well in reduction of virus particle production, we propose that Sendai virus specifically induces actin remodeling in order to promote efficient virion production. Beta- and γ-cytoplasmic actin recruitment could substitute for that of the endosomal sorting complex required for transport (ESCRT) mobilized by other enveloped viruses but apparently not used by Sendai virus.
Keywords Actins/metabolismAnimalsCell LineCytoplasm/metabolismDogsGene Expression Regulation, Viral/physiologyMicroscopy, ConfocalProtein IsoformsRNA, Small InterferingSendai virus/physiologyViral Matrix Proteins/genetics/metabolismVirion/physiologyVirus Replication/physiology
PMID: 21075412
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Research groups Groupe Christine Chaponnier (pathologie et immunologie) (171)
Multiplication virale (286)
Projects FNS: 31003A_122462
FNS: 31003A_138465 / 1
(ISO format)
MIAZZA, Vincent Xavier et al. Sendai virus induced cytoplasmic actin remodeling correlates with efficient virus particle production. In: Virology, 2011, vol. 410, n° 1, p. 7-16. https://archive-ouverte.unige.ch/unige:24018

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Deposited on : 2012-11-14

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