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Title

CCR5 Mutations Distinguish N-Terminal Modifications of RANTES (CCL5) with Agonist versus Antagonist Activity

Authors
Choi, Won-Tak
Nedellec, Rebecca
Coetzer, Mia
Colin, Philippe
Lagane, Bernard
Mosier, Donald E
Published in Journal of Virology. 2012, vol. 86, no. 18, p. 10218-20
Abstract CCR5 is the major HIV-1 entry coreceptor. RANTES/CCL5 analogs are more potent inhibitors of infection than native chemokines; one class activates and internalizes CCR5, one neither activates nor internalizes, and a third partially internalizes without activation. Here we show that mutations in CCR5 transmembrane domains differentially impact the activity of these three inhibitor classes, suggesting that the transmembrane region of CCR5, a key interaction site for inhibitors, is a sensitive molecular switch, modulating receptor activity.
Identifiers
PMID: 22787219
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Research group HIV (835)
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CHOI, Won-Tak et al. CCR5 Mutations Distinguish N-Terminal Modifications of RANTES (CCL5) with Agonist versus Antagonist Activity. In: Journal of Virology, 2012, vol. 86, n° 18, p. 10218-20. https://archive-ouverte.unige.ch/unige:23658

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Deposited on : 2012-11-01

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