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Scientific article
English

CCR5 Mutations Distinguish N-Terminal Modifications of RANTES (CCL5) with Agonist versus Antagonist Activity

Published inJournal of virology, vol. 86, no. 18, p. 10218-10220
Publication date2012
Abstract

CCR5 is the major HIV-1 entry coreceptor. RANTES/CCL5 analogs are more potent inhibitors of infection than native chemokines; one class activates and internalizes CCR5, one neither activates nor internalizes, and a third partially internalizes without activation. Here we show that mutations in CCR5 transmembrane domains differentially impact the activity of these three inhibitor classes, suggesting that the transmembrane region of CCR5, a key interaction site for inhibitors, is a sensitive molecular switch, modulating receptor activity.

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CHOI, Won-Tak et al. CCR5 Mutations Distinguish N-Terminal Modifications of RANTES (CCL5) with Agonist versus Antagonist Activity. In: Journal of virology, 2012, vol. 86, n° 18, p. 10218–10220. doi: 10.1128/JVI.00353-12
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ISSN of the journal0022-538X
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Creation2012/10/10 16:11:00
First validation2012/10/10 16:11:00
Update time2023/03/14 17:43:56
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